Allergen immunotherapy for the treatment of allergic rhinitis and/or asthma: an umbrella review

CMAJ Open
Jesse ElliottGeorge A Wells

Abstract

Allergic rhinitis and asthma are important public health concerns, yet there is no consensus about the benefits and harms of allergen-specific immunotherapy to treat these conditions. We performed an umbrella review of systematic reviews summarizing the current evidence for the benefits and harms of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). We searched MEDLINE, Embase, the Cochrane Library and the grey literature from Jan. 1, 2010 to Nov. 20, 2016 for systematic reviews of randomized controlled trials or prospectively controlled studies involving children or adults with allergic rhinitis or asthma. Outcomes were summarized narratively (benefits: total combined symptom-medication score, symptom score, medication score, disease-specific quality of life, adherence; harms: anaphylaxis, death, local and systemic reactions). Twenty-three systematic reviews were included. SCIT and SLIT were more effective than placebo for most outcomes. SCIT was better than SLIT at improving medication and symptom scores, with no differences in quality of life; however, data were limited for this comparison. Anaphylaxis and death were infrequently reported. Few reviews assessed benefits or harms among children. Allergen im...Continue Reading

References

Feb 17, 2007·BMC Medical Research Methodology·Beverley J SheaLex M Bouter
Jul 20, 2007·Annals of Internal Medicine·Kaveh G ShojaniaDavid Moher
Feb 24, 2009·Journal of Clinical Epidemiology·Beverley J SheaMaarten Boers
Dec 3, 2010·The Journal of Allergy and Clinical Immunology·Linda CoxDana Wallace
Oct 25, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée E S Larenas-LinnemannMoisés A Calderón
Jan 15, 2013·International Forum of Allergy & Rhinology·Michael T PurkeyElina Toskala
May 28, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannCarlos E Baena-Cagnani
Oct 22, 2013·The Journal of Allergy and Clinical Immunology·Moises A CalderonPascal Demoly
Jan 22, 2014·Journal of Evaluation in Clinical Practice·George Dranitsaris, Anne K Ellis
Oct 24, 2014·Expert Review of Clinical Immunology·Harold S Nelson
Sep 18, 2015·BMC Medicine·Andrea C TriccoSharon E Straus
Feb 11, 2016·Clinical and Translational Allergy·Sangeeta DhamiAziz Sheikh
Mar 24, 2016·Clinical and Translational Allergy·Sangeeta DhamiAziz Sheikh
Jun 29, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Peter S CreticosHendrik Nolte
Aug 28, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yao YangAijun Chen
Oct 12, 2016·International Journal of Technology Assessment in Health Care·Shannon E KellyTammy J Clifford

❮ Previous
Next ❯

Citations

Jun 9, 2020·Expert Opinion on Drug Safety·Cristoforo IncorvaiaErminia Ridolo
Jun 9, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Lubnaa HossenbaccusAnne K Ellis
Dec 2, 2020·PloS One·Véronique GomordLouis-P Vézina
Sep 8, 2021·Current Medical Research and Opinion·Mike TankersleyMette Bøgelund

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
M A CalderonHendrik Nolte
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Esther RöderRoy Gerth van Wijk
© 2022 Meta ULC. All rights reserved