Allergen immunotherapy in allergic rhinitis: current use and future trends

Expert Review of Clinical Immunology
Ludger KlimekThomas M Kündig

Abstract

Type-1 allergies are among the most chronic common diseases of humans. Allergen immunotherapy (AIT) is the only causative and disease-modifying treatment option besides allergen avoidance. Severe systemic adverse allergic reactions may be induced by every AIT treatment. Different approaches have been used to provide safer AIT preparations to lower or even totally overcome this risk. Areas covered: A structured literature recherche in Medline and Pubmed under inclusion of national and international guidelines and Cochrane meta-analyses has been performed aiming at reviewing clinical use of such approaches in AIT. New allergen preparations may include allergoids, recombinant allergens (recA) and modified recombinant allergens (recA) in subcutaneous as well as in mucosal immunotherapies (application e.g. using bronchial, nasal, oral and sublingual application) with sublingual being the established mucosal application route and new ways of application like intralymphatic and epicutaneous immunotherapy. Expert commentary: Immune-modifying agents like Virus-like particles and CpG-motifs, adjuvants like MPL and aluminum hydroxide are evaluated and found to increase and direct the immunological response toward immunological tolerance. ...Continue Reading

References

Aug 1, 1985·The Journal of Allergy and Clinical Immunology·L C GrammerR Patterson
Oct 1, 1982·The Journal of Allergy and Clinical Immunology·P S NormanD G Marsh
Nov 1, 1983·The Journal of Allergy and Clinical Immunology·L C GrammerR Patterson
May 1, 1997·International Archives of Allergy and Immunology·P S NormanD Proud
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J BousquetH J Malling
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J PèneJ Bousquet
Nov 20, 1998·Allergy·H J MallingE Valovirta
Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R F LockeyS C Bukantz
Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Jul 9, 2003·The Journal of Allergy and Clinical Immunology·Jean-Pierre AllamThomas Bieber
Apr 2, 2004·Nature Reviews. Immunology·Dennis M Klinman
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Marek JutelOliver Cromwell
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Thomas M KündigMartin F Bachmann
Aug 26, 2006·Allergy·E Alvarez-CuestaUNKNOWN EAACI, Immunotherapy Task Force
Oct 6, 2006·The New England Journal of Medicine·Peter S CreticosUNKNOWN Immune Tolerance Network Group
Mar 10, 2007·Current Molecular Medicine·Gary T Jennings, Martin F Bachmann
May 15, 2007·The New England Journal of Medicine·Suzanne M GarlandUNKNOWN Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators
Jul 27, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Bengt BjörksténUNKNOWN ISAAC Phase III Study Group
Aug 28, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Iwona StelmachPiotr Kuna
Sep 7, 2007·HNO·B A StuckUNKNOWN German Society for Otorhinolaryngology, Head and Neck Surgery
Nov 27, 2007·The Journal of Allergy and Clinical Immunology·Jean-Pierre AllamNatalija Novak
Sep 3, 2008·The Journal of Allergy and Clinical Immunology·Martin D ChapmanUNKNOWN CREATE consortium
Oct 28, 2008·Biological Chemistry·Gary T Jennings, Martin F Bachmann
Nov 13, 2008·The Journal of Allergy and Clinical Immunology·Gabrielle PauliHans-Jorgen Malling
Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gabriela SentiThomas M Kündig
Feb 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G SentiT M Kündig
May 30, 2009·PLoS Pathogens·Eric F TewaltChristopher C Norbury
Aug 4, 2009·The Journal of Allergy and Clinical Immunology·Friedrich HorakMartine Le Gall
Sep 8, 2009·The Journal of Allergy and Clinical Immunology·Gabriela SentiThomas M Kündig
Feb 11, 2010·The Journal of Allergy and Clinical Immunology·Linda CoxGiovanni Passalacqua
May 8, 2010·Current Opinion in Immunology·Jonathan W Yewdell
Jun 24, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David I BernsteinGary M Liss
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Stefan ZielenEnzo Madonini
Sep 10, 2010·Current Opinion in Allergy and Clinical Immunology·Gabriela SentiThomas M Kundig

❮ Previous
Next ❯

Citations

Oct 30, 2018·Allergy·Oliver PfaarLuo Zhang
Oct 27, 2018·Current Allergy and Asthma Reports·Martina AnzagheStephan Scheurer
Feb 6, 2020·Journal of the Chinese Medical Association : JCMA·Ren-Bin Tang
Nov 12, 2019·The World Allergy Organization Journal·S ZielenP J de Kam
Jan 5, 2021·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Li ShenJing Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Expert Review of Clinical Immunology
Ludger KlimekThomas M Kündig
Expert Opinion on Investigational Drugs
Peter A RickettiThomas B Casale
International Archives of Allergy and Immunology
Julia M Martínez-GómezThomas M Kündig
© 2022 Meta ULC. All rights reserved