Allergen Immunotherapy-Induced Immunoglobulin G4 Reduces Basophil Activation in House Dust Mite-Allergic Asthma Patients

Frontiers in Cell and Developmental Biology
Mulin FengJing Li

Abstract

It is unclear if allergen immunotherapy (AIT) can reduce allergy effector cell activation. We evaluated the basophil response during Dermatophagoides pteronyssinus (Der p) subcutaneous immunotherapy (SCIT) and its relationship to allergen-specific immunoglobulin G4 (sIgG4) in allergic rhinitis and/or asthma patients. The study included 55 subjects, of which 35 cases received Der p SCIT and 20 controls received standard medications. Symptom and medication scores (SMSs), sIgG4 levels, specific immunoglobulin E (sIgE) levels, allergen-induced basophil activation tests (BATs) in whole blood, and BAT inhibition assays in serum were determined at weeks 0, 4, 12, 16, 52, and 104 of SCIT. Levels of Der p sIgG4 in SCIT patients significantly increased after 12 weeks of treatment compared to week 0. Serum obtained from SCIT patients significantly inhibited basophil activation after 12 weeks of treatment. Removal of immunoglobulin G4 (IgG4) antibodies at week 104 reduced the ability of serum to block basophil activation. An increase of Der p sIgG4 rather than reduction of Der p sIgE correlated with the reduction of basophil activation during SCIT. The sIgG4 antibodies may compete with sIgE binding to allergens to form an immunoglobulin E ...Continue Reading

References

Apr 1, 1980·The Journal of Allergy and Clinical Immunology·T E Van MetreM D Valentine
Feb 1, 1993·The Journal of Allergy and Clinical Immunology·D W MacGlashan
May 1, 1993·The Journal of Allergy and Clinical Immunology·L G ArlianE Fernandez-Caldas
Jul 25, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A MichilsJ Duchateau
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K GehlharA Bufe
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Petra A WachholzStephen R Durham
Jun 23, 2004·The Journal of Allergy and Clinical Immunology·Stephen J TillStephen R Durham
Mar 3, 2005·International Archives of Allergy and Immunology·U BodtgerM Svenson
Jul 26, 2006·International Archives of Allergy and Immunology·R J J van NeervenP A Würtzen
Feb 15, 2007·Allergy·J BousquetA Sheffer
Feb 13, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Miguel González-MuñozIgnacio Moneo
Apr 1, 2008·The Journal of Allergy and Clinical Immunology·James N FrancisStephen J Till
Feb 13, 2009·Allergy·J LiUNKNOWN China Alliance of Research on Respiratory Allergic Disease
Feb 19, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R C AalberseT Rispens
Aug 4, 2009·The Journal of Allergy and Clinical Immunology·Friedrich HorakMartine Le Gall
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Anthony J Frew
Jun 10, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N LalekP Korosec
May 3, 2011·Immunology and Allergy Clinics of North America·Mohamed H ShamjiStephen R Durham
Jun 7, 2011·The Journal of Allergy and Clinical Immunology·Sevgi KelesIsil Barlan
Dec 22, 2011·American Journal of Rhinology & Allergy·Seçil Kepil ÖzdemirZeynep Mısırlıgil
Sep 6, 2012·International Archives of Allergy and Immunology·Xuxin LaiMichael D Spangfort
Dec 12, 2013·Cytometry. Part B, Clinical Cytometry·K BidadJ N G Oude Elberink
Mar 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Harold S Nelson
Mar 29, 2014·Methods in Enzymology·Jennifer M Kavran, Daniel J Leahy
Jul 30, 2014·The Journal of Allergy and Clinical Immunology·Alexandra F SantosGideon Lack
Aug 30, 2014·International Archives of Allergy and Immunology·Seçil Kepil ÖzdemirZeynep Mısırlıgil
Feb 12, 2015·The Journal of Allergy and Clinical Immunology·Alexandra F SantosGideon Lack
Sep 23, 2016·American Journal of Rhinology & Allergy·Ethem ŞahinCemal Cingi
Oct 14, 2017·American Journal of Rhinology & Allergy·Ethem ŞahinCemal Cingi
May 8, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mulin FengJing Li

❮ Previous
Next ❯

Citations

Nov 19, 2020·Allergy·Kensuke MiyakeHajime Karasuyama
Dec 15, 2020·Current Allergy and Asthma Reports·Gabija DrazdauskaitėMohamed H Shamji
Nov 6, 2020·The Journal of Allergy and Clinical Immunology·Didier G EboVito Sabato

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
flow
FCS
flow cytometry
Antibody
ELISA

Software Mentioned

FCS Express

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.