Allergen immunotherapy: what is the added value of real-world evidence from retrospective claims database studies?

Expert Review of Respiratory Medicine
Philippe DevillierMathieu Molimard

Abstract

Introduction: Randomized controlled trials (RCTs) show that allergen immunotherapy (AIT) has proven long-term efficacy in patients with allergic rhinitis (AR). However, RCTs have limited generalizability and there is growing recognition that real-world evidence (RWE) is necessary to provide complementary data to those of RCTs, and corroborate their findings. Until recently, data from the real-world setting investigating the benefits of AIT for the treatment of patients with grass and birch pollen-associated AR were sparse, but new retrospective claims database studies from France and Germany have confirmed the sustained benefits of grass and birch pollen AIT in terms of significantly reduced progression of AR and asthma, and a significantly decreased risk of new-onset asthma.Areas covered: Here, we review the value of RWE used alongside data from traditional RCTs, and its potential strengths and limitations, and summarize the findings of the recent RWE studies investigating the benefits of AIT for the management of patients with grass and birch pollen-associated AR.Expert opinion: There is growing recognition of the necessity and value of RWE as a complement to data acquired in RCTs, to better understand the effects of AIT trea...Continue Reading

References

Dec 25, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kobi SadeShmuel Kivity
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Esther RöderRoy Gerth van Wijk
Sep 22, 2009·The Journal of Allergy and Clinical Immunology·Thomas B CasaleGiovanni Passalacqua
Jan 29, 2011·The Journal of Allergy and Clinical Immunology·David J CostaUNKNOWN Languedoc-Roussillon Teaching General Practitioners Group
Dec 20, 2011·Therapeutic Advances in Respiratory Disease·Tunis Ozdoganoglu, Murat Songu
Jan 17, 2012·The Journal of Allergy and Clinical Immunology·Moisés A CalderónPascal Demoly
Oct 16, 2013·Current Opinion in Allergy and Clinical Immunology·Gianenrico SennaGiorgio Walter Canonica
Dec 10, 2013·BMC Medicine·Moisés A CalderónPascal Demoly
Apr 1, 2014·The World Allergy Organization Journal·Giorgio Walter CanonicaOsman Yusuf
Jul 15, 2015·The Journal of Allergy and Clinical Immunology·Marek JutelCezmi A Akdis
Aug 26, 2015·Breathe·David PriceAlison Chisholm
Sep 16, 2015·The Journal of Allergy and Clinical Immunology·Jochen SchmittEike Gunther Wüstenberg
Sep 30, 2015·The World Allergy Organization Journal·Claus BachertGiovanni Passalacqua
Jan 14, 2016·Current Allergy and Asthma Reports·Cristoforo IncorvaiaErminia Ridolo
Oct 21, 2016·Expert Review of Clinical Immunology·Pascal DemolyKarl-Christian Bergmann
Jan 25, 2017·Patient Preference and Adherence·Marie-Luise LembergRalph Mösges
Sep 14, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Susanne HalkenAntonella Muraro
Feb 8, 2018·The Journal of Allergy and Clinical Immunology·Jean-Pierre AllamEike Gunther Wüstenberg
Oct 26, 2018·Advances in Therapy·Lawrence BlondeNeil S Skolnik
Oct 30, 2018·Allergy·Oliver PfaarLuo Zhang
Apr 6, 2019·The Journal of Allergy and Clinical Immunology·Annabelle BédardUNKNOWN MASK study group
Apr 8, 2019·Allergy·Jean BousquetUNKNOWN ARIA Working Group
Sep 14, 2019·Clinical and Translational Allergy·J Jean BousquetUNKNOWN MASK Study Group

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Citations

Mar 3, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Moisés A Calderón, Leonard B Bacharier
Jun 16, 2021·Current Opinion in Allergy and Clinical Immunology·Giovanni Passalacqua, Diego Bagnasco
Oct 23, 2021·Fundamental & Clinical Pharmacology·Mathieu CharvériatUNKNOWN SFPT Translational Research in Pharmacology group

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