Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1

Journal of Leukocyte Biology
Stephania LibrerosVijaya Iragavarapu-Charyulu

Abstract

Metastasis is the primary cause of mortality in women with breast cancer. Metastasis to the lungs is greater in patients with pulmonary inflammatory illnesses. It is unknown how pre-existing pulmonary inflammation affects mammary tumor progression. We developed a novel breast cancer model in which pulmonary inflammation is induced in mice prior to tumor cell implantation. In the present study, we determined how pre-existing allergen-induced inflammation changes the pulmonary microenvironment to exacerbate tumor metastasis. We showed that pre-existing pulmonary inflammation in mammary tumor bearers is associated with: 1) an increase in growth of the primary tumor and metastasis; 2) an increase in the expression of a glycoprotein known as CHI3L1; and 3) increase in the levels of myeloid populations in their lungs. We also showed that myeloid derived cells from the lungs of allergic tumor bearers produce higher amounts of CHI3L1 than the saline controls. We previously showed that CHI3L1 induces the expression of proinflammatory and protumorigenic molecules. In this study, we show that CHI3L1 knockout tumor bearers with pre-existing allergic pulmonary inflammation had decreased levels of myeloid-derived cells, decreased levels of p...Continue Reading

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Citations

Aug 28, 2015·Journal of Leukocyte Biology·Stephania Libreros, Vijaya Iragavarapu-Charyulu
Sep 16, 2020·Signal Transduction and Targeted Therapy·Ting ZhaoQiang You

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