Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness

American Journal of Respiratory Cell and Molecular Biology
E HamelmannE W Gelfand

Abstract

The mechanisms underlying the development of airway hyperresponsiveness are not fully delineated. We addressed this question by studying the effects of passive sensitization with anti-OVA IgE on the development of altered airway responsiveness (AR) following local challenge with OVA in normal and athymic mice. Both normal and athymic BALB/c mice developed allergen-specific immediate cutaneous hypersensitivity after passive sensitization with anti-OVA IgE. In contrast, the combination of local challenge with allergen via the airways and passive sensitization triggered the development of airway hyperresponsiveness only in normal but not in athymic mice. Treatment of athymic mice with IL-5 significantly increased eosinophil accumulation in the lungs after local challenge with OVA; increased airway reactivity was only observed in athymic mice which received anti-OVA IgE, not an unrelated IgE, plus IL-5 treatment and airway challenge with OVA. These findings identify the requirement for allergen-specific IgE and IL-5 for the development of airway hyperresponsiveness following allergen challenge via the airways.

Citations

Jul 6, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Brombacher
Jul 1, 1997·Clinical Reviews in Allergy & Immunology·I Kimber, R J Dearman
Jan 25, 2003·Current Allergy and Asthma Reports·Heidi Isenberg-FeigAndrea Keane-Myers
Apr 6, 2004·Immunology and Allergy Clinics of North America·Judah A Denburg, Paul K Keith
Aug 28, 1998·Research in Immunology·V P KurupP S Murali
Aug 15, 2000·The International Journal of Biochemistry & Cell Biology·Y Riffo-VasquezD Spina
May 3, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y Riffo-VasquezC P Page
May 17, 2000·Current Opinion in Pulmonary Medicine·M F Lipscomb, J A Wilder
Jul 26, 2006·International Archives of Allergy and Immunology·R J J van NeervenP A Würtzen
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·A HaczkuE W Gelfand
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·A HaczkuE W Gelfand
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·A HaczkuE W Gelfand
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·P G KnottC P Bertrand
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·J C KipsR A Pauwels
Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Richard LeighMark D Inman
Feb 25, 1999·American Journal of Respiratory Cell and Molecular Biology·J A MacLeanG T De Sanctis
Aug 26, 1999·American Journal of Respiratory Cell and Molecular Biology·E SalikK Sperber
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·E HamelmannE W Gelfand
Jan 27, 2004·American Journal of Respiratory Cell and Molecular Biology·Christian TaubeErwin W Gelfand
Apr 19, 2005·American Journal of Respiratory Cell and Molecular Biology·Debbie L ChouLisa A Miller
Mar 11, 2006·American Journal of Respiratory Cell and Molecular Biology·Ninghai WangPatricia W Finn
Jun 22, 1999·The Journal of Clinical Investigation·A MishraM E Rothenberg
Apr 24, 2007·Environmental Health Perspectives·Arthur L PennLarry Lomax
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J MäkeläE W Gelfand
Dec 1, 2001·Expert Opinion on Biological Therapy·K BlümchenE Hamelmann
May 9, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S LajoieM Wills-Karp
May 31, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K IvoryC Nicoletti
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Julia G KoopmansJaring S van der Zee
Aug 6, 2005·Pharmacology & Therapeutics·Michelle M Epstein
Jan 27, 2015·Annual Review of Immunology·John F KearneyR Glenn King
Jul 8, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S I MayrF-T Liu
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J J van NeervenP A Würtzen
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U HerzH Renz
Aug 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D QuarcooE Hamelmann
Jun 5, 2002·Current Opinion in Allergy and Clinical Immunology·Simon P HoganMarc E Rothenberg
Jul 13, 2017·American Journal of Respiratory Cell and Molecular Biology·Christopher G McKnightFred D Finkelman
Aug 3, 2004·Journal of Applied Physiology·Richard LeighMark D Inman

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