PMID: 22563781May 9, 2012Paper

Allergen-specific responses of CD19(high) and CD19(low) B Cells in Non-IgE-mediated food allergy of late eczematous reactions in atopic dermatitis: presence of IL-17- and IL-32-producing regulatory B cells (Br17 & Br32)

Inflammation & Allergy Drug Targets
Joonyong Noh, Geunwoong Noh

Abstract

Food allergies are important etiologic factors in atopic dermatitis. CD19 is a B-cell-specific cell-surface molecule, with a critical role in B-cell activation. Recently, B cells showed independent two subpopulations as CD19(high) and CD19(low). The allergen-specific responses of the CD19(high) and CD19(low) B-cell subpopulations were investigated in patients with non-IgE-mediated food allergy. Five milk-allergic subjects and eight milk-tolerant subjects were selected by a double-blind placebo-controlled food challenge. Peripheral blood mononuclear cells (PBMCs) were stimulated in vitro with casein or ovalbumin and stained with monoclonal antibodies to distinguish the B-cell subsets. After allergen stimulation, CD19(high) B cells increased in the number and the fraction in PBMCs in the milk-tolerant group, whereas those remained unchanged in the milk-allergic group. These responses were constant, regardless of the kind of food allergen (milk or egg). The resulting CD19(high)/CD19(low) B-cell ratio increased markedly in the milk-tolerant group after allergen stimulation, but was unchanged in the milk-allergic group. IL-10, IL-17, IL-32 and TGF-β- producing regulatory B cells and Foxp3-expressing regulatory B cells were identifie...Continue Reading

Citations

Nov 28, 2012·Journal of Clinical Immunology·Honghao WangXueqiang Hu
Dec 12, 2012·Clinical Reviews in Allergy & Immunology·Marco H-K HoChristopher Chang
Dec 12, 2012·The British Journal of Nutrition·Béatrice GleizePatrick Borel
Nov 16, 2013·The Journal of Allergy and Clinical Immunology. in Practice·Marcel M BergmannPhilippe A Eigenmann
Apr 2, 2014·IEEE Transactions on Bio-medical Engineering·Lei DingYoon-Hee Cha
Jun 25, 2016·Clinical Reviews in Allergy & Immunology·Zahava Vadasz, Elias Toubi
Apr 21, 2018·Allergy, Asthma & Immunology Research·Jing LuoHuabin Li
Aug 8, 2018·Allergologia et immunopathologia·Aline Aparecida de Lima LiraJefferson Russo Victor

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