PMID: 8941677Dec 1, 1996Paper

Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis

The Journal of Investigative Dermatology
Thomas WerfelAlexander Kapp

Abstract

The majority of allergen-specific T cells derived from inhalant allergen patch test lesions in patients with atopic dermatitis were previously found to produce a restricted type-2 cytokine pattern. Recent studies, however, have revealed that in chronic eczematous skin lesions of patients with atopic dermatitis, expression of the type-1 cytokine interferon-gamma predominates. To evaluate cytokine production by allergen-specific T cells in chronic atopic dermatitis, we established house dust mite (Dermatophagoides pteronyssinus)-specific T-cell clones from the dermis of chronic skin lesions of sensitized adult patients with atopic dermatitis. Frequencies of skin-derived T cells proliferating in the presence of Dermatophagoides pteronyssinus were between one in 138 and one in 4255, indicating that only a minority of skin-infiltrating T cells are allergen specific. When these cells were analyzed for their capacity to produce interferon-gamma, the majority (71%) of these cells were found to express interferon-gamma mRNA and to secrete interferon-gamma protein, either alone or in combination with interleukin-4. Phenotypic analysis revealed that 15% of skin-infiltrating allergen-specific T cells were CD8+. No selection of Vbeta elemen...Continue Reading

Citations

Feb 5, 1999·Clinical and Experimental Immunology·A LonatiG De Panfilis
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Wistokat-WülfingT Werfel
Apr 20, 1999·The Journal of Clinical Investigation·J M SpergelR S Geha
Nov 13, 2001·Allergy·K BreuerT Werfel
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryouji YagiMasato Kubo
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K Matsui, A Nishikawa
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C A Akdis, M Akdis
Apr 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C AntúnezM Blanca
Mar 15, 2005·Clinical and Experimental Immunology·E A HadleyP D Arkwright
Aug 27, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K BreuerT Werfel
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karl J AichbergerRudolf Valenta
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahul PurwarThomas Werfel
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana HenninoJean-François Nicolas
Mar 3, 2010·Annual Review of Immunology·Rudolf ValentaSusanne Vrtala
Nov 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Min Ju Kim, Se-Young Choung
Feb 13, 2016·Science Translational Medicine·Rachael JarrettGraham Ogg
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T Holgate
Mar 16, 2002·Current Allergy and Asthma Reports·Mübeccel AkdisCezmi A Akdis
May 22, 2001·The British Journal of Dermatology·C C BanfieldJ I Harper
Apr 23, 2003·The Journal of Experimental Medicine·Michel GillietYong-Jun Liu
Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WormT Zuberbier
Jul 7, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·U WahnL Nilsson
Aug 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi KonishiHitoshi Mizutani
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peck Y OngDonald Y M Leung
Aug 24, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Yuko KawakamiToshiaki Kawakami
Jan 27, 2010·Experimental Dermatology·Jan D BosJ Henk Sillevis Smitt
Aug 2, 2007·Biological & Pharmaceutical Bulletin·Su-Jin LeeCheung-Seog Park
Mar 1, 2006·Expert Review of Clinical Immunology·Judith A Woodfolk
Aug 25, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Nlandu Roger NgatuNarufumi Suganuma
Jul 3, 2016·American Journal of Clinical Dermatology·Diane Wang, Lisa A Beck
Mar 11, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lennart M RoesnerThomas Werfel
Jun 18, 2017·Current Opinion in Allergy and Clinical Immunology·Raffaela CampanaRudolf Valenta
Apr 1, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T LappT Reinhard
Jul 7, 2018·Frontiers in Immunology·Wojciech BaranKnut Schäkel
Apr 13, 2019·Immunological Reviews·Jillian M RichmondJohn E Harris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.