Allergenic characterization of Tyrophagus putrescentiae using sera from occupationally exposed farmers

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
L G ArlianM van Hage-Hamsten

Abstract

Allergic sensitivity to storage mites is common in farmers and others who work in environments where hay and grain are handled, stored, or processed. The clinical importance of storage mite-induced allergy in these individuals is generally unknown in the United States. Tyrophagus putrescentiae is a common storage mite, the allergenicity of which has not been characterized. The purpose of this study was to characterize the allergenicity of Tyrophagus putrescentiae. Crossed immunoelectrophoresis (CIE) and crossed radioimmunoelectrophoresis (CRIE) were performed to characterize the allergens of this mite using the sera from 24 occupationally exposed farmers RAST-positive to T. putrescentiae. CRIE analysis of T. putrescentiae extract utilizing individual farmers' sera identified 14 allergens. The number of allergens that bound IgE in the individual sera ranged from 5 to 11. Sensitivity to the different allergens varied both within and between patients but 100% of the farmers' sera recognized the same five allergens precipitated by CIE. Fifty percent of patients' sera recognized one additional. Forty-two and 21% of the sera had IgE binding to six and seven of the allergens, respectively. The results of this study showed that farmers...Continue Reading

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Citations

Feb 24, 2000·Archives of Insect Biochemistry and Physiology·F OrtegoP Castañera
Mar 15, 2002·Current Allergy and Asthma Reports·L G Arlian
Aug 8, 2002·Current Allergy and Asthma Reports·Larry G ArlianJacqueline S Neal
Dec 13, 2005·Clinical and Diagnostic Laboratory Immunology·Kyoung Yong JeongTai-Soon Yong
Dec 1, 2001·Annual Review of Entomology·Larry G Arlian
Jan 16, 2007·International Journal of Hygiene and Environmental Health·Krzysztof SolarzMagdalena Peszke
Nov 8, 2014·Asia Pacific Allergy·Sheng-Jie YuJaw-Ji Tsai
May 3, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M KronqvistM van Hage-Hamsten
Sep 18, 2012·Journal of Food Protection·Ju-Hyun JeonHoi-Seon Lee
Jan 10, 2003·American Journal of Veterinary Research·Larry G ArlianRobert L Glass
May 10, 2005·Clinical and Diagnostic Laboratory Immunology·Kyoung Yong JeongTai-Soon Yong
Jul 18, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J C WinckJ M Sapage

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