Abstract
Vaccines have had a dramatic effect on the prevalence of communicable diseases, but, in selected individuals, the injection presents a risk of anaphylaxis. Fortunately, most people have no allergic reactions to vaccines. In egg-allergic individuals, care must be taken before administering specific vaccines; the algorithm provided in this article gives specific recommendations for skin testing and desensitization. This algorithm is not needed for individuals receiving the measles-mumps-rubella vaccine because the risk of anaphylaxis is extremely low, even in those with known egg-protein sensitivity. Some individuals have gelatin sensitivity, which may cause anaphylaxis. Selected vaccines contain antibiotic drugs, so it is important to note if an individual has any known drug sensitivity, especially to neomycin, polymyxin B, or amphotericin B. Lastly, vaccine preservatives may cause reactions, but this occurs very infrequently.
References
Jun 1, 1992·The Journal of Pediatrics·M B FasanoH A Sampson
Feb 1, 1983·The Journal of Pediatrics·J J HermanR Schneiderman
May 11, 1995·The New England Journal of Medicine·J M JamesH A Sampson
Apr 1, 1993·The Journal of Allergy and Clinical Immunology·J M KelsoJ W Yunginger
Feb 1, 1997·Pediatrics in Review·R Agha
Jun 1, 1997·Pediatrics·R T ChenS C Hadler
Jun 19, 1998·Journal of the American Academy of Dermatology·J G MarksJ S Taylor
Jul 31, 1998·Vaccine·M SakaguchiS Inouye
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·T NakayamaH Kuno-Sakai
Feb 27, 1999·Contact Dermatitis·A PatriziA Tosti
Aug 13, 1999·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·T BaydarG Sahin
Mar 9, 2000·Vaccine·M Sakaguchi, S Inouye
Jun 10, 2000·Science·D Malakoff
Citations
Sep 23, 2009·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·K WeisserB Keller-Stanislawski
Feb 12, 2014·Expert Review of Vaccines·Christian Herzog
May 18, 2010·The Veterinary Clinics of North America. Small Animal Practice·George E Moore, Harm HogenEsch
Sep 22, 2007·Journal of Travel Medicine·Kristina Van De WinkelJef Van den Ende
Aug 2, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Robert A Wood
Apr 20, 2005·Vaccine·Frank R Brennan, Gordon Dougan
Jun 5, 2007·The Journal of Allergy and Clinical Immunology·Robert A WoodUNKNOWN Clinical Immunization Safety Assessment (CISA) Network Hypersensitivity Working Group
Nov 16, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jennifer HehnMatthias Goebeler
Apr 9, 2015·Clinical and Translational Medicine·Fabrizio FranceschiniCarlo Caffarelli
Aug 9, 2003·Expert Opinion on Drug Safety·Robert M JacobsonGregory A Poland
Apr 17, 2015·Journal of Cutaneous Medicine and Surgery·L Alexandra Kuritzky, Melanie Pratt
Oct 14, 2005·Journal of the American Veterinary Medical Association·George E MooreLawrence T Glickman
Jun 24, 2017·Clinical and Experimental Dermatology·I J MoonS D Kim
Feb 24, 2006·The Medical Journal of Australia·Barbara E EldredAllan L Nash
Sep 3, 2008·Pediatrics·Robert A WoodUNKNOWN Hypersensitivity Working Group of the Clinical Immunization Safety Assessment (CISA) Network