Allergens TRP a swITCH to Initiate Type 2 Immunity.

Immunity
Charlotte E CheadleCatherine M Hawrylowicz

Abstract

Allergens induce type-2 immunity, but unresolved questions remain about initiation of this response. In this issue, Perner et al. propose that cutaneous activation of TRPV1+ sensory neurons by protease allergens stimulates release of substance P to induce migration of Th2-skewing CD301b+ DC to draining lymph nodes.

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