Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis: MR Imaging of Airway Mucus Contrasts as a Tool for Diagnosis

Radiology
Gaël DournesFrançois Laurent

Abstract

Purpose To assess the diagnostic accuracy of mucus contrast characterization by using magnetic resonance (MR) imaging to discriminate allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF). Materials and Methods The study was approved by the local Ethics Committee, and all patients or their parents gave written informed consent. One hundred ten consecutive patients with CF were screened between January 2014 and July 2015. All patients underwent a non-contrast material-enhanced MR protocol that included routine T1-weighted and T2-weighted sequences. The presence of mucus with both high T1 and low T2 signal intensities and the so-called inverted mucoid impaction signal (IMIS) sign was qualitatively and quantitatively assessed by two physicians who were blinded to all other data. The reference standard for a diagnosis of ABPA was the criteria of the Cystic Fibrosis Foundation Consensus Conference. ABPA status was followed up for 1 year. Reproducibility was assessed by using the κ test, correlation was assessed by using the Spearman coefficient, and diagnostic accuracy was assessed by calculating the sensitivity and specificity of IMIS. Results One hundred eight patients with CF were included (mean age, 20 years ± 1...Continue Reading

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Citations

Jun 22, 2018·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Feb 10, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jean DelacosteAlain Sauty
Mar 2, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Harm A W M TiddensPierluigi Ciet
Feb 6, 2019·Indian Journal of Pediatrics·Savinay KapurManisha Jana
Dec 18, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jason C WoodsTalissa A Altes
Jun 28, 2020·Pediatric Pulmonology·Jennifer L GoralskiJason C Woods
Jan 5, 2021·Current Opinion in Pulmonary Medicine·Valliappan MuthuRitesh Agarwal
Jan 18, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Brian C M LiBradley S Quon
Dec 22, 2020·Chest·Gaël DournesJason C Woods
Jun 9, 2019·European Journal of Radiology·Gaël DournesFrançois Laurent
Feb 16, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·John RefaitGaël Dournes
Jun 4, 2021·Journal of Asthma and Allergy·Andrew J WardlawCatherine H Pashley
Jun 15, 2021·Clinical Radiology·J GeigerC J Kellenberger

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