Allergic contact dermatitis caused by isobornyl acrylate in the Enlite glucose sensor and the Paradigm MiniMed Quick-set insulin infusion set

Contact Dermatitis
Anne HermanMartin Mowitz

Abstract

The FreeStyle Libre glucose sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this sensor has been identified as one of the culprit allergens. To report on the presence of IBOA in devices produced by Medtronic, namely, the Enlite sensor and the insulin infusion set Paradigm MiniMed Quick-set. Five patients reacting to the glucose sensor Enlite and/or the insulin infusion set Paradigm MiniMed Quick-set observed in three clinics (two Belgian and one Swedish) were patch tested with the baseline and other series, as well as with IBOA; four of them also with pieces of adhesive patches from the devices, and two with a thin layer chromatogram of Enlite glucose sensor extracts. Gas chromatography-mass spectrometry (GC-MS) analyses were performed. Four patients reacted to IBOA and one to colophonium, a known allergen in Enlite, and three to the adhesive part of the sensor or the insulin infusion set. IBOA was identified in the sensor by GC-MS, and its presence was indicated in the infusion set. IBOA is a contact allergen in Enlite glucose sensor, and likely also in the infusion set. Therefore, these devices are not suitable alternatives for patients sensitized to the FreeStyle Libre sensor.

References

Sep 1, 1995·Contact Dermatitis·A M BusschotsA Dooms-Goossens
Mar 16, 2018·Journal of Diabetes Science and Technology·Stefanie KamannLutz Heinemann
May 1, 2018·Contact Dermatitis·Stefano PassanisiGiovanni B Pajno
Feb 14, 2019·Journal of Diabetes Investigation·Yusuke MineDaisuke Matsuura
Feb 19, 2019·Contact Dermatitis·Martin MowitzMagnus Bruze
Jun 18, 2019·Contact Dermatitis·Heli S I HyryHannele M Virtanen

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Citations

Oct 28, 2019·Contact Dermatitis·Anne HermanMarie Baeck
Jan 9, 2020·Dermatitis : Contact, Atopic, Occupational, Drug·Olivier AertsAn Goossens
Mar 8, 2020·Contact Dermatitis·Carmen Vidal-AlbaredaDavid González-de-Olano
Jul 2, 2020·Contact Dermatitis·Josefin UlriksdotterMagnus Bruze
Jul 16, 2020·Contact Dermatitis·Nils Hamnerius, Martin Mowitz
Jan 23, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·N WagnerE Oppel
Jul 18, 2020·Contact Dermatitis·Ulrik Ahrensbøll-FriisJeanne D Johansen
Dec 5, 2020·Dermatitis : Contact, Atopic, Occupational, Drug·Emily M Hartsough, Sara A Hylwa
Mar 30, 2021·Current Allergy and Asthma Reports·Erica B LeeAshley Wysong
Jun 30, 2021·Contact Dermatitis·María-Elena Gatica-OrtegaAna Giménez-Arnau
Sep 13, 2021·The British Journal of Dermatology·J UlriksdotterM Mowitz
Nov 10, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefanie KamannEva Oppel

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