PMID: 20646670Jul 22, 2010Paper

Allergic contact dermatitis from vitamin E: the experience at Mayo Clinic Arizona, 1987 to 2007

Dermatitis : Contact, Atopic, Occupational, Drug
Alison K Adams, Suzanne M Connolly

Abstract

Vitamin E, of which the most biologically active form is alpha-tocopherol, has become widely known for its antioxidant effects. It has been ingested or applied topically for purported anti-aging effects and for cosmetic enhancement. To determine whether the incidence of allergic contact dermatitis from vitamin E has increased in recent years. With the approval of the Mayo Clinic institutional review board, we retrospectively analyzed patch-test data from patients tested from June 1987 through December 2007. A total of 2,950 patients were patch-tested during this period, and 18 patients (0.61%) had positive reactions to alpha-tocopherol; 6 (0.53%) of 1,136 patients tested from June 1987 through December 1997 had positive results, and 12 (0.66%) of 1,814 patients tested from January 1998 through December 2007 had positive results (p = .69). Vitamin E appears to be a relatively rare contact allergen in our experience.

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