Allergic diseases and the effect of inhaled epinephrine in children with acute bronchiolitis: follow-up from the randomised, controlled, double-blind, Bronchiolitis ALL trial

The Lancet. Respiratory Medicine
Håvard Ove SkjervenK C Lødrup Carlsen

Abstract

Although use of inhaled bronchodilators in infants with acute bronchiolitis is not supported by evidence-based guidelines, it is often justified by the belief in a subgroup effect in individuals developing atopic disease. We aimed to assess if inhaled epinephrine during acute bronchiolitis in infancy would benefit patients with later recurrent bronchial obstruction, atopic eczema, or allergic sensitisation. In the randomised, double-blind, multicentre Bronchiolitis ALL trial, 404 infants with moderate-to-severe acute bronchiolitis were recruited from eight hospitals in Norway to receive either inhaled epinephrine or saline up to every second hour throughout the hospital stay. Randomisation was done centrally, and the two study medications (20 mg/mL racemic epinephrine or 0.9% saline) were prepared in identical bottles. The dose given depended on the infant's weight: 0.10 mL, less than 5 kg; 0.15 mL, 5-6.9 kg; 0.2 mL, 7-9.9 kg; and 0.25 mL, 10 kg or more; all dissolved in 2 mL of 0.9% saline before nebulisation. The primary outcome was the length of hospital stay. In this follow-up study, 294 children were reinvestigated at 2 years of age with an interview, a clinical examination, and a skin prick test for 17 allergens, determin...Continue Reading

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Citations

Feb 24, 2016·Expert Review of Respiratory Medicine·Silvia VandiniMarcello Lanari
Mar 15, 2016·The British Journal of Dermatology·T L BerentsP Gjersvik
Feb 15, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·Z AliS F Thomsen
Nov 30, 2018·Expert Review of Respiratory Medicine·Matti Korppi
Sep 28, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Rosemary MegalaaGustavo Nino
Aug 31, 2019·PloS One·Leif Bjarte RolfsjordKarin C Lødrup Carlsen
Mar 24, 2020·ERJ Open Research·Jon Olav Gjengstø HunderiHåvard Ove Skjerven
Jun 25, 2016·Thorax·Orianne DumasCarlos A Camargo
Jul 13, 2021·The Open Respiratory Medicine Journal·Amar Al ShibliHassib Narchi

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