PMID: 38289Jul 1, 1979

Allergic encephalitis, rabies antibodies, and the blood/brain barrier

The Journal of Laboratory and Clinical Medicine
J F Bell, G J Moore

Abstract

Similarity of the syndromes of rabies and of encephalomyelitis resulting from rabies vaccination poses a problem in differential diagnosis that has had tragic consequences. That difficulty may also be largely responsible for the traditional belief that rabies is inexorably fatal, in that recovery from paralysis is interpreted as evidence that the disease was postvaccinal encephalomyelitis rather than rabies. Diagnosis is additionally complicated by presence of rabies antibodies in serum in both conditions. However, we have found that rabies antibodies elicited by vaccination do not pass the blood/brain barrier to enter the fluids of the CNS in EAE, the experimental counterpart of postvaccinal encephalomyelitis; whereas antibodies are present in high titer as a result of production in situ after recovery from rabies. Therefore a ratio of antibody concentrations of greater than 1:10 in CSF and serum indicates chronic rabies or recovery from that disease.

Related Concepts

Antibodies, Viral
Blood - Brain Barrier Anatomy
Encephalomyelitis, Postexanthem
Freund's Adjuvant
Cavia porcellus
Rabies Vaccines
Rabies virus

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Acute Disseminated Encephalomyelitis

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system. Discover the latest research on acute disseminated encephalomyelitis here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.