Allergic interstitial nephritis possibly related to sunitinib use

The American Journal of Geriatric Pharmacotherapy
Anand Khurana

Abstract

Sunitinib is an oral multitargeted inhibitor indicated for the treatment of renal cell carcinoma. This report describes a case of allergic interstitial nephritis possibly related to this agent. A 69-year-old female patient with a history of metastatic renal cell carcinoma after left radical nephrectomy presented to our nephrology clinic after completing 2 courses of sunitinib therapy. The patient was noted to have progressive kidney dysfunction with proteinuria, together with peripheral eosinophilia and eosinophiluria, which developed during the first of 2 cycles of sunitinib therapy. Her concomitant medications included atenolol, triamterene/hydrochlorothiazide, amlodipine, and multivitamin tablets, all of which she had been receiving at stable doses over the previous 2 years. There were no other over-the-counter medications involved and other possible causes of interstitial nephritis were excluded. The proteinuria, eosinophilia, and eosinophiluria worsened with the second course and resolved after sunitinib discontinuation, which resulted in initial stabilization followed by slight improvement in kidney function. The Naranjo Adverse Drug Reaction Probability Scale score for this event was 7, indicating a probable association ...Continue Reading

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May 1, 2012·Current Oncology Reports·Suzanne R HaymanVesna D Garovic
Nov 29, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon K WinnJames E Marsh
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