PMID: 9433938Jan 20, 1998Paper

Allergic reactions to ampicillin. Studies on the specificity and selectivity in subjects with immediate reactions

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A RomanoM Blanca

Abstract

Ampicillin (AMP) is a drug that has been prescribed extensively. Reactions that have been reported include exanthema, desquamative contact eczema, urticaria and anaphylaxis. Experimental evidence indicates that the side chain of AMP is a structure that may induce a selective immune response either at the humoral or lymphocyte T-cell level. With regard to IgE reactions, the selectivity and specificity of the response needs to be studied in humans. To study the specificity of the IgE response in a group of subjects who had an immediate allergic reaction after the administration of AMP. Subjects developing an immediate response (anaphylaxis or urticaria) after the administration of AMP or an aminopenicillin derivative with the same side chain as AMP were studied. Skin tests were made to determinants generated from benzyl penicillin (BP): benzyl penicilloyl (BPO) and minor determinant mixture (MDM), as well as amoxicillin (AX) and AMP. Specific IgE antibodies were determined to benzyl penicilloyl polylisine (BPO-PLL), amoxicilloyl-polylisine (AX-PLL) and ampicilloyl-polylisine (AMP-PLL). The specificity of the IgE antibody response was studied by RAST and RAST inhibition. Subjects were classified in three categories: group A: those...Continue Reading

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Citations

May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D M ForrestP M Dodek
Oct 16, 2013·Current Opinion in Infectious Diseases·Jason Trubiano, Elizabeth Phillips
Dec 24, 2005·Expert Opinion on Drug Safety·Rebeca Rodriguez-PenaMaria Jose Torres
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Jan 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BlancaA DeWeck
Jan 6, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T FernandezM Blanca
Jul 7, 2015·Rapid Communications in Mass Spectrometry : RCM·Debasish SwainGananadhamu Samanthula
Oct 29, 2013·Journal of Virological Methods·Julie MedinaIsabelle Legastelois
Jan 8, 2017·Rapid Communications in Mass Spectrometry : RCM·Sukanya PandetiThota Jagadeswar Reddy
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BlancaC Juárez
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L SanzA L De Weck
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Jun 5, 2019·Expert Review of Clinical Immunology·Natalia Blanca-LopezMiguel Blanca
Jun 26, 2015·Current Opinion in Allergy and Clinical Immunology·Miguel Blanca, Bernard Y-H Thong

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