Allergic reactions to beta-lactams

Expert Opinion on Drug Safety
Rebeca Rodriguez-PenaM J Torres

Abstract

Allergy to beta-lactam antibiotics is the most frequent cause of drug-induced immunological reactions, although the prevalence is not exactly known. IgE- and T-cell-dependent responses are the main mechanisms involved, although other immunological mechanisms can also participate, especially in haematological abnormalities, such as immune haemolytic anaemia or thrombocytopoenia. Aside from their frequency, the clinical entities reported nowadays have changed little since penicillin was first used. The variation in beta-lactams consumption through the year has modified the pattern and specificities of allergic reactions for IgE and T cell responses. Benzylpenicillin is no longer the beta-lactams most frequently prescribed and other chemical structures, with new or modified haptens, have progressively replaced it. This is relevant for the diagnostic evaluation and management of beta-lactam hypersensitivity.

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Citations

Apr 2, 2008·Current Allergy and Asthma Reports·Brian A BaldoNghia H Pham
Jun 4, 2008·AIDS·Neil H ShearElizabeth J Phillips
Jul 1, 2008·Expert Review of Clinical Pharmacology·Amit S KalgutkarJonathan Bauman
Mar 1, 2006·Expert Opinion on Drug Safety·Rakesh Chandra
Dec 15, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M J TorresM Blanca
Aug 10, 2017·Chemistry : a European Journal·Raúl Pérez-RuízM Consuelo Jiménez
Jun 5, 2019·Expert Review of Clinical Immunology·Natalia Blanca-LopezMiguel Blanca
Nov 9, 2010·Molecular Diagnosis & Therapy·Abdelbaset A ElzagallaaiGideon Koren

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