Allergic response to glucagon injection as a result of insulin contamination.

The Journal of Clinical Endocrinology and Metabolism
A E KitabchiF K Baskin

Abstract

A 25-year-old obese woman with adult onset diabetes, with known insulin allergy, was evaluated for her insulin response to glucagon. Intravenous injection of glucagon produced severe generlaized allergic reaction. Skin tests with various insulin and glucagon preparations showed allergic reaction to be most pronounced with beef regular single peak and single component insulin, pork regular single peak, beef lente single peak, and neutral regular (beef-pork) single peak insulin. Allergic reactions to numerous glucagon preparations were found to be directly proportional to the amount of insulin contamination in those preparations. Purification of one glucagon lot by column chromatography verified the presence of proinsulin and insulin contaminants in the preparation.

Citations

Apr 1, 1991·Annals of Emergency Medicine·R B VukmirD M Yealy
Mar 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Kasper Meidahl PetersenMikkel Bring Christensen
Oct 29, 1998·The American Journal of Physiology·A DickerJ Nedergaard
Nov 1, 1981·The American Journal of Physiology·H SacksA E Kitabchi

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