Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO

Allergy, Asthma & Immunology Research
Jisun YoonSoo-Jong Hong

Abstract

The nature of allergic rhinitis (AR) in preschool aged children remains incompletely characterized. This study aimed to investigate the prevalence of AR and its associated risk factors in preschool-aged children and to assess the clinical utility of fractional exhaled nitric oxide (FeNO). This general population-based, cross-sectional survey included 933 preschool-aged (3- to 7-year-old) children from Korea. Current AR was defined as having nasal symptoms within the last 12 months and physician-diagnosed AR. The prevalence of current AR in preschool children was 17.0% (156/919). Mold exposure (adjusted odds ratio [aOR], 1.67; 95% confidence interval [CI], 1.15-2.43) and the use of antibiotics (aOR, 1.97; 95% CI, 1.33-2.90) during infancy were associated with an increased risk of current AR, whereas having an older sibling (aOR, 0.52; 95% CI, 0.35-0.75) reduced the risk. Children with current atopic AR had significantly higher geometric mean levels of FeNO compared to those with non-atopic rhinitis (12.43; range of 1standard deviation [SD], 7.31-21.14 vs 8.25; range of 1SD, 5.62-12.10, P=0.001) or non-atopic healthy children (8.58; range of 1SD, 5.51-13.38, P<0.001). The FeNO levels were higher in children with current atopic AR...Continue Reading

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Citations

Nov 28, 2017·Allergy, Asthma & Immunology Research·Xu ZhangLuo Zhang
Apr 5, 2019·American Journal of Rhinology & Allergy·Zhong BingLiu Shi-Xi
Aug 9, 2018·Allergy, Asthma & Immunology Research·Yoko InoueMotohiro Ebisawa
Jul 25, 2019·Allergy, Asthma & Immunology Research·You Hoon JeonHae Ran Lee
Aug 3, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Nachi EbiharaMasataka Sunagawa
Aug 9, 2018·Allergy, Asthma & Immunology Research·Do Hyun KimSoo Whan Kim
Feb 26, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Cheryn Yu Wei ChooChih-Yung Chiu
May 29, 2020·Respiration; International Review of Thoracic Diseases·Claudia CrimiNunzio Crimi

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