Abstract
The nature of allergic rhinitis (AR) in preschool aged children remains incompletely characterized. This study aimed to investigate the prevalence of AR and its associated risk factors in preschool-aged children and to assess the clinical utility of fractional exhaled nitric oxide (FeNO). This general population-based, cross-sectional survey included 933 preschool-aged (3- to 7-year-old) children from Korea. Current AR was defined as having nasal symptoms within the last 12 months and physician-diagnosed AR. The prevalence of current AR in preschool children was 17.0% (156/919). Mold exposure (adjusted odds ratio [aOR], 1.67; 95% confidence interval [CI], 1.15-2.43) and the use of antibiotics (aOR, 1.97; 95% CI, 1.33-2.90) during infancy were associated with an increased risk of current AR, whereas having an older sibling (aOR, 0.52; 95% CI, 0.35-0.75) reduced the risk. Children with current atopic AR had significantly higher geometric mean levels of FeNO compared to those with non-atopic rhinitis (12.43; range of 1standard deviation [SD], 7.31-21.14 vs 8.25; range of 1SD, 5.62-12.10, P=0.001) or non-atopic healthy children (8.58; range of 1SD, 5.51-13.38, P<0.001). The FeNO levels were higher in children with current atopic AR...Continue Reading
References
Dec 1, 1989·The American Review of Respiratory Disease·P K JefferyA B Kay
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Mar 30, 2001·The Journal of Biological Chemistry·S StranoG Blandino
May 19, 2001·Genes & Development·A VassilevM L DePamphilis
Aug 13, 2005·Cell·Jianbin HuangDuojia Pan
Aug 29, 2006·Lancet·Sally E Wenzel
Nov 3, 2007·Genes & Development·Bin ZhaoKun-Liang Guan
Nov 17, 2009·Cell·Claudio AlarcónJoan Massagué
Mar 30, 2010·BMC Bioinformatics·Mariana L NevesAlberto Pascual-Montano
Jan 5, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·John M WeilerUNKNOWN Joint Council of Allergy, Asthma and Immunology
Jun 15, 2011·Oncogene·L AngusF J Gunn-Moore
Feb 18, 2012·International Immunology·Ildikó UngváriCsaba Szalai
Mar 21, 2012·PloS One·Ildikó UngváriCsaba Szalai
Oct 2, 2012·BMC Medical Genomics·Orsolya Lautner-CsorbaCsaba Szalai
Apr 18, 2013·PloS One·Susana MoleirinhoFrank J Gunn-Moore
Aug 14, 2013·PloS One·Orsolya Lautner-CsorbaCsaba Szalai
May 6, 2014·The Lancet. Respiratory Medicine·Deborah A MeyersStephen T Holgate
Jul 22, 2014·Developmental Cell·John E MahoneyWellington V Cardoso
Jul 22, 2014·Nature Immunology·Golnaz VahediJohn J O'Shea
Oct 1, 2014·The Pharmacogenomics Journal·A GézsiC Szalai
Oct 8, 2014·Physiological Reviews·Stefano PiccoloMichelangelo Cordenonsi
Dec 6, 2014·Acta Biochimica Et Biophysica Sinica·Meng-Xin Yin, Lei Zhang
Dec 6, 2014·Acta Biochimica Et Biophysica Sinica·Beibei MaoZengqiang Yuan
Dec 7, 2014·Journal of Molecular Cell Biology·Alexander W LangeJeffrey A Whitsett
Jan 13, 2015·Tuberculosis and Respiratory Diseases·Ho Il Yoon
Feb 12, 2015·The New England Journal of Medicine·Louis-Philippe Boulet, Paul M O'Byrne
Mar 3, 2015·Allergy, Asthma & Immunology Research·Kalthoum TizaouiAgnès Hamzaoui
Mar 3, 2015·Allergy, Asthma & Immunology Research·Chun-Ni ZhaoLi-Fang Hou
Jan 8, 2016·Allergy, Asthma & Immunology Research·Yan ChenJing Li
May 10, 2016·The Journal of Allergy and Clinical Immunology·Tze Khee ChanBevin P Engelward
Citations
Nov 28, 2017·Allergy, Asthma & Immunology Research·Xu ZhangLuo Zhang
Apr 5, 2019·American Journal of Rhinology & Allergy·Zhong BingLiu Shi-Xi
Aug 9, 2018·Allergy, Asthma & Immunology Research·Yoko InoueMotohiro Ebisawa
Jul 25, 2019·Allergy, Asthma & Immunology Research·You Hoon JeonHae Ran Lee
Aug 3, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Nachi EbiharaMasataka Sunagawa
Aug 9, 2018·Allergy, Asthma & Immunology Research·Do Hyun KimSoo Whan Kim
Feb 26, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Cheryn Yu Wei ChooChih-Yung Chiu
May 29, 2020·Respiration; International Review of Thoracic Diseases·Claudia CrimiNunzio Crimi