PMID: 9438494Jan 23, 1998Paper

Allergic rhinitis to grass pollen: measurement of inflammatory mediators of mast cell and eosinophils in native nasal fluid lavage and in serum out of and during pollen season

The Journal of Allergy and Clinical Immunology
G Di LorenzoC Caruso

Abstract

In allergic rhinitis, mast cells, activated by cross-linking of allergen to mast cell-bound specific IgE, release both vasoactive mediators related to the early nasal symptoms and chemotactic mediators that attract inflammatory cells, such as eosinophils, related to the late-phase response. We have analyzed, during and out of pollen season, in blood and nasal fluid from patients allergic to grass pollen, histamine and tryptase to monitor the early phase markers and eosinophil and eosinophil cationic protein (ECP) to monitor the late phase. Twenty patients were enrolled in the study. As a control, we studied 10 nonatopic subjects. Mediators and eosinophils were assessed in blood and nasal fluid. Histamine was tested only in nasal fluid. During pollen season, tryptase but not histamine increased in nasal fluids from patients (2.96 vs 0.22 U/ml, p = 0.001) and correlated with symptom scores (r(s) = 0.63, p = 0.003). Tryptase was not detected in serum. Eosinophils increased in nasal cytology (17.0% vs 2.0%, p = 0.001) and in the blood (265 vs 12.7 x 10(6) L, p = 0.001) from patients, but they did not correlate with symptom scores. ECP increased only in the nasal lavage (1633 vs 1.30 ng/ml, p = 0.001) and correlated with symptom sco...Continue Reading

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Citations

Mar 5, 2005·The Journal of Allergy and Clinical Immunology·Peter H HowarthPhilip E Silkoff
Jan 27, 2004·Veterinary Immunology and Immunopathology·Sandra JollyDaniel Desmecht
Aug 22, 2002·International Immunopharmacology·Olivier A R ThometHans-Uwe Simon
Sep 7, 2013·Journal of Extracellular Vesicles·Kenneth W WitwerFred Hochberg
Feb 23, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Moritz GrögerMatthias F Kramer
Jul 6, 2010·Pulmonary Pharmacology & Therapeutics·Z DiamantR Gerth van Wijk
Apr 10, 2009·The Journal of Allergy and Clinical Immunology·Gabriele Di LorenzoAnne Marie Ditto
Aug 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J PatouC Bachert
Nov 24, 2004·São Paulo Medical Journal = Revista Paulista De Medicina·Clóvis Eduardo Santos GalvãoFábio Fernandes Morato Castro
Feb 5, 2011·International Archives of Allergy and Immunology·Gabriele Di LorenzoDanilo Di Bona
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Di LorenzoC Caruso
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P W HellingsJ L Ceuppens
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J HalesW R Thomas
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C BezS Zielen
Jan 16, 2010·International Journal of Immunopathology and Pharmacology·G Di LorenzoR Corrocher
Mar 3, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jaw-Ji TsaiMey-Fan Lee
Jan 4, 2006·International Journal of Immunopathology and Pharmacology·G Di LorenzoG B Rini
Feb 5, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Nur Sabrina IdroseShyamali C Dharmage

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