Allergoids for Allergy Treatment

Recent Patents on Inflammation & Allergy Drug Discovery
J CarnésV Iraola

Abstract

Chemically modified allergen extracts, known as allergoids, are commonly used for treating allergic patients. In general terms, the concept of allergoids implies allergen extracts with a reduction of their allergenicity maintaining their immunogenicity. Different methods to obtain allergoids have been developed in the past years, opening attractive lines of research. To review the different approaches to allergoid development as well as their characterization, mechanism of action and efficacy and safety issues. A revision and analysis of the different types of allergoids has been performed, with special attention to patents submitted and granted in the last years. Additionally, updated information about the mechanism of action and clinical evidence and safety of allergoids has been discussed. Principally, allergoids are obtained by the polymerization of native allergen extracts with aldehydes, including formaldehyde or glutaraldehyde. However, recent patents and publications about different chemical modifications have been presented, as well as about the use of new adjuvants with allergoids. Regarding the characterization, allergoids require more sophisticated analytical methods than native extracts, as a consequence of their p...Continue Reading

Citations

May 30, 2021·Molecular Immunology·Azahara González-RuizJerónimo Carnés
Dec 3, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Raquel MoyaJerónimo Carnés

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