AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice

The World Allergy Organization Journal
Josef SingerErika Jensen-Jarolim

Abstract

Atopics have a lower risk for malignancies, and IgE targeted to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or adaptive immune surveillance can confer protection against tumors remains unclear. We aimed to investigate the effects of active and passive immunotherapy to the tumor-associated antigen HER-2 in three murine models differing in Epsilon-B-cell-receptor expression affecting the levels of expressed IgE. We compared the levels of several serum specific anti-HER-2 antibodies (IgE, IgG1, IgG2a, IgG2b, IgA) and the survival rates in low-IgE ΔM1M2 mice lacking the transmembrane/cytoplasmic domain of Epsilon-B-cell-receptors expressing reduced IgE levels, high-IgE KN1 mice expressing chimeric Epsilon-Gamma1-B-cell receptors with 4-6-fold elevated serum IgE levels, and wild type (WT) BALB/c. Prior engrafting mice with D2F2/E2 mammary tumors overexpressing HER-2, mice were vaccinated with HER-2 or vehicle control PBS using the Th2-adjuvant Al(OH)3 (active immunotherapy), or treated with the murine anti-HER-2 IgG1 antibody 4D5 (passive immunotherapy). Overall, among the three strains of mice, HER-2 vaccination induced significantly higher levels of HER-2 specific IgE and IgG1 in high-IgE KN1, while l...Continue Reading

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Citations

Apr 30, 2020·Current Opinion in Allergy and Clinical Immunology·Judit Fazekas-SingerErika Jensen-Jarolim
Mar 6, 2021·The World Allergy Organization Journal·Denisa FerastraoaruErika Jensen-Jarolim
Sep 4, 2021·Journal of Clinical Immunology·Serdar AlÖzkan Karaman

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BETA
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transgenic

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GraphPad Prism

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