Allergy and eosinophil-associated gastrointestinal disorders (EGID).

Current Opinion in Immunology
Charles W DeBrosse, Marc E Rothenberg

Abstract

Eosinophil-associated gastrointestinal disorders (EGIDs) are characterized by an inappropriate accumulation of eosinophils within the gastrointestinal tract. The underlying etiology and pathophysiology that lead to the development of EGID are far from elucidated. However, there is growing evidence to support the role of aeroallergens and food allergens in the pathogenesis of these disorders. Recent advances have highlighted the role of Th2-driven cytokines in the development of EGID, and clinical studies have verified that children and adults with EGID often have positive skin testing to food allergens. The most common form of EGID, eosinophilic esophagitis (EE), has garnered intense investigation following an increased recognition over the past decade. Recently, there have been several important studies providing insight into both the cellular mechanisms governing EE and clinical therapies directed toward the treatment of EE. In the article herein, we will review the most recent scientific advances influencing our understanding of EGID with special emphasis on the role of allergens in the pathogenesis of EGID.

References

Apr 9, 2001·Immunological Reviews·M E RothenbergS P Hogan
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Matthew I FoggJonathan M Spergel
Aug 27, 2004·The New England Journal of Medicine·Richard J NoelMarc E Rothenberg
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Alex Straumann, Hans-Uwe Simon
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Seema S AcevesJohn F Bastian
Feb 3, 2006·The Journal of Clinical Investigation·Carine BlanchardMarc E Rothenberg
Sep 2, 2006·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Charles W DeBrosseMarc E Rothenberg
Oct 7, 2006·Dysphagia·Scott P PentiukAjay Kaul
Oct 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael R KonikoffMarc E Rothenberg
Nov 30, 2006·Journal of Pediatric Gastroenterology and Nutrition·Emmanuel K O SiawRichard J Jackson
Jan 6, 2007·Journal of Pediatric Gastroenterology and Nutrition·Richard KirschErnest Cutz
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Seema S AcevesDavid H Broide
Jan 30, 2007·The Journal of Allergy and Clinical Immunology·Amal H Assa'adMarc E Rothenberg
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Jonathan M SpergelChris A Liacouras
Jun 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Jennifer Z BullockMarc E Rothenberg
Sep 4, 2007·The Journal of Allergy and Clinical Immunology·Shabnam ForoughiCalman Prussin
Oct 9, 2007·Gastroenterology·Glenn T FurutaUNKNOWN First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees
Dec 7, 2007·Gastrointestinal Endoscopy Clinics of North America·Philip E Putnam
Dec 7, 2007·Gastrointestinal Endoscopy Clinics of North America·Margaret H Collins
Dec 7, 2007·Gastrointestinal Endoscopy Clinics of North America·Alex Straumann
Dec 7, 2007·Gastrointestinal Endoscopy Clinics of North America·Carine Blanchard, Marc E Rothenberg
Dec 7, 2007·Gastrointestinal Endoscopy Clinics of North America·Chris A Liacouras
Feb 29, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sumita Roy-GhantaDavid A Katzka
Apr 16, 2008·The Journal of Allergy and Clinical Immunology·Miguel L SteinMarc E Rothenberg

❮ Previous
Next ❯

Citations

Jul 31, 2012·Seminars in Immunopathology·Seema AcevesMargaret H Collins
Aug 10, 2012·Current Allergy and Asthma Reports·Zhaleh J Amini-VaughanDavid P Huston
Feb 24, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Ali G Saad
May 16, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maren von Köckritz-Blickwede, Victor Nizet
Mar 5, 2013·Digestive Diseases and Sciences·Zili ZhangYasemen Eroglu
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Charles W DeBrosseJames P Franciosi
Aug 25, 2009·Gastroenterology·Sylvia BrugmanEdward E S Nieuwenhuis
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N A MolfinoG P Geba
Jul 17, 2013·Journal of Cellular and Molecular Medicine·Jae-Hyun LeeJung-Won Park
Jan 12, 2010·Immunology·Victoria E L StubbsKamala D Patel
Aug 4, 2015·Current Allergy and Asthma Reports·Antonella Cianferoni, Jonathan M Spergel
Jul 27, 2015·Immunology and Allergy Clinics of North America·Praveen Akuthota, Peter F Weller
Aug 27, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Hideaki MoritaKenji Matsumoto
May 19, 2016·Expert Review of Clinical Pharmacology·Susan HuaNicholas J Talley
Jun 12, 2014·United European Gastroenterology Journal·Bram D van RhijnAlbert J Bredenoord
Jan 16, 2016·Pediatric Gastroenterology, Hepatology & Nutrition·Jong Sub ChoiGyeong Hoon Kang
Aug 16, 2011·Advances in Anatomic Pathology·Jennifer M HurrellShelby D Melton
Aug 6, 2009·Current Opinion in Gastroenterology·Thomas T MacDonald, Antonio Di Sabatino
Jun 10, 2017·World Journal of Gastroenterology : WJG·Kodjo-Kunale AbassaYun-Wei Guo
Aug 27, 2015·Journal of Pediatric Gastroenterology and Nutrition·Geetanjalee SadiWael El-Matary
May 31, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alfredo J Lucendo, Piedad López-Sánchez
May 30, 2019·BMJ Case Reports·Federica SulloSalvatore Leonardi
Dec 22, 2016·Nature Reviews. Gastroenterology & Hepatology·Anna Nowak-WegrzynGideon Lack
May 1, 2021·Seminars in Immunopathology·Alessandra GurtnerIsabelle C Arnold
Jun 9, 2010·Archives of Pathology & Laboratory Medicine·Muriel GenevayAnne-Laure Rougemont

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.