Allergy and the cardiovascular system.

Clinical and Experimental Immunology
M TriggianiG Marone

Abstract

The most dangerous and life-threatening manifestation of allergic diseases is anaphylaxis, a condition in which the cardiovascular system is responsible for the majority of clinical symptoms and for potentially fatal outcome. The heart is both a source and a target of chemical mediators released during allergic reactions. Mast cells are abundant in the human heart, where they are located predominantly around the adventitia of large coronary arteries and in close contact with the small intramural vessels. Cardiac mast cells can be activated by a variety of stimuli including allergens, complement factors, general anesthetics and muscle relaxants. Mediators released from immunologically activated human heart mast cells strongly influence ventricular function, cardiac rhythm and coronary artery tone. Histamine, cysteinyl leukotrienes and platelet-activating factor (PAF) exert negative inotropic effects and induce myocardial depression that contribute significantly to the pathogenesis of anaphylactic shock. Moreover, cardiac mast cells release chymase and renin that activates the angiotensin system locally, which further induces arteriolar vasoconstriction. The number and density of cardiac mast cells is increased in patients with i...Continue Reading

References

Oct 1, 1992·Journal of Molecular and Cellular Cardiology·M Triggiani, F H Chilton
Dec 1, 1991·British Journal of Anaesthesia·C StellatoG Marone
Jan 1, 1988·Annals of the New York Academy of Sciences·G MaroneC Vigorito
Dec 1, 1987·Journal of the American College of Cardiology·C VigoritoF Rengo
May 1, 1995·International Archives of Allergy and Immunology·G MaroneM Adt
Jan 1, 1997·International Journal of Clinical & Laboratory Research·C VigoritoG Marone
Oct 4, 2000·Physiological Reviews·G MontrucchioG Camussi
Sep 5, 2002·The Journal of Allergy and Clinical Immunology·Stephen F Kemp, Richard F Lockey
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Richard Pumphrey
Dec 14, 2004·Current Opinion in Pulmonary Medicine·Joshua Allan Lawson, Ambikaipakan Senthilselvan
Jan 5, 2005·Trends in Immunology·Gianni MaroneAmato de Paulis
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·Fred D FinkelmanRichard T Strait
Oct 27, 2005·International Journal of Cardiology·Nicholas G Kounis
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·F Estelle R Simons
Oct 20, 2006·Biochimica Et Biophysica Acta·Ken Karasawa
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Phil LiebermanF Estelle R Simons
May 15, 2007·Immunological Reviews·Alicia C ReidRoberto Levi
Aug 11, 2007·The Journal of Allergy and Clinical Immunology·F Estelle R SimonsAndrew F Walls
Jul 11, 2007·Current Opinion in Allergy and Clinical Immunology·David Bk Golden
Jul 11, 2007·Current Opinion in Allergy and Clinical Immunology·Ulrich R Mueller
Jan 4, 2008·The New England Journal of Medicine·Peter VadasJupiter Yeung

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Citations

May 4, 2013·North American Journal of Medical Sciences·V MuktaAshok Kumar Das
Jan 1, 2012·Anesthesia, Essays and Researches·Omar ItaniJamil Shaaban
Oct 19, 2013·Internal and Emergency Medicine·Erminia RidoloTiziana Meschi
Jan 15, 2015·The New England Journal of Medicine·Mandakolathur R MuraliBhatraphol Tingpej
Jul 28, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eric S EdwardsRonald Goldwater
Jul 17, 2012·The Journal of Emergency Medicine·Katherine KrollEdward Ullman
Oct 19, 2011·The Journal of Allergy and Clinical Immunology·Allan LinnebergSteen Z Abildstrøm
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·F Estelle R Simons
May 9, 2009·British Journal of Pharmacology·S K WalshC L Wainwright
Jul 17, 2013·Journal of Veterinary Emergency and Critical Care·Daniella L Shmuel, Yonaira Cortes
Jun 22, 2010·Allergy·M Ben-Shoshan, A E Clarke
Jan 18, 2011·British Journal of Clinical Pharmacology·Linda Nel, Efrem Eren
Jun 10, 2014·Allergy·A MuraroUNKNOWN EAACI Food Allergy and Anaphylaxis Guidelines Group
Jan 17, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michail AlevizosTheoharis C Theoharides
Jul 6, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Edgardo José JaresUNKNOWN Latin America Drug Allergy Interest Group
Jan 6, 2015·The Journal of Allergy and Clinical Immunology·Marta WawrzyniakLiliane Michalik
Dec 10, 2013·International Journal of Cardiology·Daniel P Potaczek
Apr 7, 2015·Immunology and Allergy Clinics of North America·David B K Golden
Aug 16, 2011·International Journal of Cardiology·G F CalogiuriN G Kounis
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Valerio PravettoniElide A Pastorello
Jul 6, 2014·The Journal of Allergy and Clinical Immunology·Sunday ClarkCarlos A Camargo
Oct 9, 2012·The Journal of Allergy and Clinical Immunology·Peter VadasGary Liss
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Maria NassiriMargitta Worm
Aug 23, 2016·Primary Care·Lorenzo HernandezGeorge G A Pujalte
Oct 28, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Phillip LiebermanStephen A Tilles
Oct 22, 2015·International Journal of Immunopathology and Pharmacology·Krzysztof Pałgan, Zbigniew Bartuzi
Feb 9, 2017·Clinical and Molecular Allergy : CMA·Maria Teresa VenturaGiorgio Walter Canonica
Feb 9, 2011·Journal of Intensive Care Medicine·Fredric M PieracciErnest E Moore
Nov 9, 2017·Environmental and Molecular Mutagenesis·Giovanni FioritoUNKNOWN EXPOsOMICS consortium‡
Sep 29, 2012·International Archives of Allergy and Immunology·Anna Sala-CunillMar Guilarte
Dec 15, 2017·Clinical and Translational Allergy·Alberto Alvarez-PereaMaría L Baeza
Apr 21, 2018·American Journal of Hematology·Elisabeth FarhatEmmanuel J Favaloro
Jul 23, 2009·Current Opinion in Cardiology·Jonathan Golledge, Paul E Norman
Aug 22, 2018·A&A Practice·Jan Schumacher
Jun 15, 2010·Current Opinion in Allergy and Clinical Immunology·Keith J Simons, F Estelle R Simons
Jun 11, 2014·Current Opinion in Allergy and Clinical Immunology·Massimo TriggianiErminia Ridolo
Jun 30, 2010·Current Opinion in Allergy and Clinical Immunology·F Estelle R Simons
Nov 23, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Charles TacquardPaul M Mertes
Apr 16, 2015·Texas Heart Institute Journal·Hemal BhattArchana Saxena

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