Allergy influences the inflammatory status of the brain and enhances tau-phosphorylation.

Journal of Cellular and Molecular Medicine
Heela SarlusMircea Oprica

Abstract

Despite the existing knowledge regarding the neuropathology of Alzheimer's disease (AD), the cause of sporadic forms of the disease is unknown. It has been suggested that systemic inflammation may have a role, but the exact mechanisms through which inflammatory processes influence the pathogenesis and progress of AD are not obvious. Allergy is a chronic inflammatory disease affecting more than 20% of the Western population, but the effects of allergic conditions on brain functions are largely unknown. The aim of this study was to investigate whether or not chronic peripheral inflammation associated with allergy affects the expression of AD-related proteins and inflammatory markers in the brain. On the basis of previously described models for allergy in mice we developed a model of chronic airway allergy in mouse, with ovalbumin as allergen. The validity of the chronic allergy model was confirmed by a consistent and reproducible eosinophilia in the bronchoalveolar lavage (BAL) fluid of allergic animals. Allergic mice were shown to have increased brain levels of both immunoglobulin (Ig) G and IgE with a widespread distribution. Allergy was also found to increase phosphorylation of tau protein in the brain. The present data suppor...Continue Reading

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Citations

Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Heela SarlusMarianne Schultzberg
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Xiuzhe WangMarianne Schultzberg
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Feb 24, 2017·Biomolecular Concepts·Marta BolósJesús Avila
Mar 3, 2020·Journal of Alzheimer's Disease : JAD·Jin ZhangChun-Ling Dai
Jul 6, 2021·Frontiers in Neuroscience·Arthur Sefiani, Cédric G Geoffroy

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Methods Mentioned

BETA
transgenic
bronchoalveolar lavage
transgenics

Software Mentioned

Multi Gauge
Statistica
Statsoft

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