PMID: 7535982Dec 1, 1994Paper

Allergy to ingested cereals in atopic children

Allergy
L RäsänenT Reunala

Abstract

Clinical features, hypersensitivity mechanisms, and differential diagnosis of cereal allergy or intolerance were investigated in children with atopic dermatitis (AD). On oral provocation, 18 children exhibited a positive response to wheat, three to rye, one to barley, and one to oats. Cereal-induced symptoms were dermatologic, gastrointestinal, or oropharyngeal, and their onset after provocation was immediate (eight cases), delayed (14 cases), or both immediate and delayed (one case). A combination of type I allergy tests (prick test, RAST, and histamine-release test) detected all immediate reactors and 9/14 delayed reactors. Of the five subjects remaining negative in these tests, three were positive in the patch or lymphocyte-proliferation tests. Subjects with cereal allergy or intolerance frequently possessed IgE, IgA, and IgG antibodies against gliadin, but only one of these children was HLA-DR3-positive, and none had reticulin antibodies typical of celiac disease. Combining tests of immediate and delayed hypersensitivity can confirm allergy to cereals in a more reliable way. The coexistence of cereal allergy and celiac disease seems to be rare.

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Citations

Nov 7, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B SimonatoA Curioni
Jan 22, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M LehtoH Alenius
Jun 23, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·D de Boissieu, C Dupont
May 19, 2010·Expert Review of Clinical Immunology·Ludovico AbenavoliGiovanni Addolorato
Nov 22, 2017·Clinical Reviews in Allergy & Immunology·Akanksha SharmaPremendra D Dwivedi
Feb 17, 2006·Alimentary Pharmacology & Therapeutics·C HischenhuberR Ward
Oct 11, 2005·International Archives of Allergy and Immunology·Claudia ConstantinRudolf Valenta
Jul 4, 2003·Current Opinion in Allergy and Clinical Immunology·Kati Palosuo
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroaki MatsuoEishin Morita
Nov 4, 2000·Scandinavian Journal of Gastroenterology·K KaukinenP Collin
Jun 9, 2018·Clinical Reviews in Allergy & Immunology·Alexandra WalterAndreas Wollenberg
Aug 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K-M JärvinenH Suomalainen

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