Alleviating neurodegeneration in Drosophila models of PolyQ diseases

Cerebellum & Ataxias
Zhe LongHong Jiang

Abstract

Polyglutamine (polyQ) diseases are a group of neurodegenerative conditions, induced from CAG trinucleotide repeat expansion within causative gene respectively. Generation of toxic proteins, containing polyQ-expanded tract, is the key process to cause neurodegeneration. Till now, although polyQ diseases remain uncurable, numerous therapeutic strategies with great potential have been examined and have been proven to be effective against polyQ diseases, including diverse small biological molecules and many pharmacological compounds mainly through prevention on formation of aggregates and inclusions, acceleration on degradation of toxic proteins and regulation of cellular function. We review promising therapeutic strategies by using Drosophila models of polyQ diseases including HD, SCA1, SCA3 and SBMA.

References

Jun 1, 1990·Science·Y Sanchez, S L Lindquist
Dec 1, 1994·Nature·D A ParsellS Lindquist
Jun 3, 1998·Methods : a Companion to Methods in Enzymology·C B Phelps, A H Brand
Mar 10, 2000·Science·P Kazemi-Esfarjani, S Benzer
Mar 24, 2000·Science·G M RubinS Lewis
Jun 9, 2000·Annual Review of Neuroscience·H Y Zoghbi, H T Orr
Aug 25, 2000·Human Molecular Genetics·A McCampbellK H Fischbeck
Apr 5, 2002·Trends in Genetics : TIG·David C Rubinsztein
Apr 30, 2002·Human Molecular Genetics·Brinda RavikumarDavid C Rubinsztein
Jun 29, 2002·Nature Neuroscience·Alexander V PanovJ Timothy Greenamyre
Aug 20, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sameez Hasan, Michael O Hottiger
Oct 3, 2002·Nature Cell Biology·David L StenoienMichael A Mancini
Feb 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emma HocklyGillian P Bates
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Barbara L ApostolLeslie Michels Thompson
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Aug 29, 2003·Cellular and Molecular Life Sciences : CMLS·H Okazawa
Sep 25, 2003·Human Molecular Genetics·Andrej Michalik, Christine Van Broeckhoven

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Citations

Jun 26, 2020·Frontiers in Neuroscience·Davin LeeSung Bae Lee
Oct 5, 2018·Frontiers in Cellular Neuroscience·Linlin WanHong Jiang
Sep 17, 2021·Npj Aging and Mechanisms of Disease·Chih-Chieh YuChih-Fei Kao

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Methods Mentioned

BETA
histone acetylation
transgenic

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