Alleviation of Acute Lung Injury in Rats with Sepsis by Resveratrol via the Phosphatidylinositol 3-Kinase/Nuclear Factor-Erythroid 2 Related Factor 2/Heme Oxygenase-1 (PI3K/Nrf2/HO-1) Pathway

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Yu WangRong Zhang

Abstract

BACKGROUND Resveratrol (Res) is a type of polyphenol found in many plants, which can protect important organs from the damage induced by sepsis. However, the exact mechanism of its protective effect has not been established. This study investigated the effect of Res on the PI3K/Nrf2/HO-1 signaling pathway in rats with sepsis-induced acute lung injury (ALI). MATERIAL AND METHODS Male Wistar rats were treated with 30 mg/kg Res by intraperitoneal administration for 1 hour immediately after cecal ligation and puncture. Levels of MIP-2, IL-18, and IL-10 in bronchoalveolar lavage fluid (BALF) were determined. Lung tissues were collected to measure the wet-to-dry (W/D) ratios, oxidative stress index, and lung injury scores. Expression levels of Akt, p-Akt, HO-1, Nrf-2, and active caspase-3 proteins were determined by western blotting; expression of HO-1 mRNA was determined by RT-PCR. RESULTS Treatment with Res significantly decreased the levels of MIP-2 and IL-18 and increased IL-10 in the BALF of rats with sepsis-induced ALI. In addition, Res also effectively reduced the W/D lung weight ratio, lung injury score, and the levels of MDA (malondialdehyde) and 8-OHdG. Conversely, Res increased SOD (superoxide dismutase) activity in the lu...Continue Reading

Citations

Feb 8, 2019·Oxidative Medicine and Cellular Longevity·Qinmei LiuXinxin Ci
Apr 11, 2019·Current Pharmaceutical Design·Tanzir RafeMd Abu Taher Sagor
Mar 23, 2020·Experimental and Molecular Pathology·Hongyan RuanMengyuan Zhang
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Jan 27, 2021·Critical Care : the Official Journal of the Critical Care Forum·Elisabeth C van der SlikkeHjalmar R Bouma
Mar 5, 2021·Frontiers in Pharmacology·Mohammad Bagher MajnooniJavier Echeverría
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Feijie ZhaoSongling Zhang
Jul 11, 2021·Life Sciences·Liping LiLixin Sun

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Methods Mentioned

BETA
nuclear translocation
bronchoalveolar
lavage
ELISA
electrophoresis
MDA

Software Mentioned

SPSS
LineGene 9600 Plus

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