Alleviation of glucose repression of maltose metabolism by MIG1 disruption in Saccharomyces cerevisiae.

Applied and Environmental Microbiology
C J KleinJ Nielsen

Abstract

The MIG1 gene was disrupted in a haploid laboratory strain (B224) and in an industrial polyploid strain (DGI 342) of Saccharomyces cerevisiae. The alleviation of glucose repression of the expression of MAL genes and alleviation of glucose control of maltose metabolism were investigated in batch cultivations on glucose-maltose mixtures. In the MIG1-disrupted haploid strain, glucose repression was partly alleviated; i.e., maltose metabolism was initiated at higher glucose concentrations than in the corresponding wild-type strain. In contrast, the polyploid delta mig1 strain exhibited an even more stringent glucose control of maltose metabolism than the corresponding wild-type strain, which could be explained by a more rigid catabolite inactivation of maltose permease, affecting the uptake of maltose. Growth on the glucose-sucrose mixture showed that the polypoid delta mig1 strain was relieved of glucose repression of the SUC genes. The disruption of MIG1 was shown to bring about pleiotropic effects, manifested in changes in the pattern of secreted metabolites and in the specific growth rate.

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Citations

Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·S OstergaardJ Nielsen
Aug 12, 2010·FEMS Microbiology Letters·Judith DietvorstH Yde Steensma
Apr 15, 2014·FEMS Microbiology Reviews·Jan SteenselsKevin J Verstrepen
Apr 17, 2015·Journal of Industrial Microbiology & Biotechnology·Xue LinDong-Guang Xiao
Apr 27, 2002·Applied and Environmental Microbiology·Jack T Pronk
Dec 8, 2005·Applied and Environmental Microbiology·Virve VidgrenJohn Londesborough
Apr 20, 2005·Letters in Applied Microbiology·L LiW Huang
Jan 25, 2013·Journal of Industrial Microbiology & Biotechnology·Jing ZouDongguang Xiao
May 25, 2015·World Journal of Microbiology & Biotechnology·Cui-Ying ZhangDong-Guang Xiao
Aug 30, 2002·Applied and Environmental Microbiology·Mickel L A JansenJack T Pronk
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·Elke Nevoigt
Aug 22, 2009·Microbiology·Wanwipa VongsangnakJens Nielsen
Jun 8, 2018·Journal of Industrial Microbiology & Biotechnology·Victor E Balderas-HernándezRadhakrishnan Mahadevan
Feb 19, 1998·Microbiology·Christopher J L KleinJens Nielsen
May 16, 2001·Fungal Genetics and Biology : FG & B·R P Andrade, M Casal
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