Alleviation of lead acetate-induced nephrotoxicity by Moringa oleifera extract in rats: highlighting the antioxidant, anti-inflammatory, and anti-apoptotic activities

Environmental Science and Pollution Research International
Mohamed M Abdel-DaimGadah Albasher

Abstract

Lead (Pb) is an environmental toxicant; its consumption can induce renal deficits. In this study, we explored the possible protective efficiency of Moringa oleifera extract (MOE) against lead acetate (PbAc)-mediated reprotoxicity. Four experimental groups of seven rats each were used: control, PbAc, MOE, and MOE+PbAc groups. All groups were given their respective treatment for 4 weeks. PbAc impaired the oxidative/antioxidative balance in the renal tissue, as shown by the decreased antioxidant proteins (glutathione, glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase) and increased oxidants (lipid peroxidation and nitric oxide). Additionally, PbAc enhanced the progression of kidney inflammation by increasing tumor necrosis factor-alpha, interleukin-1 beta, and nuclear factor kappa B associated with upregulation of inducible nitric oxide synthase. Moreover, a dysregulation in the apoptotic-regulating proteins (Bax, caspase-3, and Bcl2) were recorded upon PbAc exposure. Remarkably, MOE oral administration restored redox homeostasis, suppressed the inflammatory and apoptotic responses in the kidney tissue. Our findings point out that MOE could be used as an alternative remedy to overcome the adverse ef...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Jan 1, 1984·Methods in Enzymology·H Aebi
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Jan 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jin XuLi-hong Xu
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Brahma N SinghH B Singh
Nov 19, 2014·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Manoj Kumar VelagaBettaiya Rajanna
Jun 23, 2016·Drug Design, Development and Therapy·Mohamed A DkhilAhmed Esmat Abdel Moneim
Jun 3, 2017·Journal of Clinical and Diagnostic Research : JCDR·Roopashree MallyaPrasanna Mithra
Dec 8, 2017·Critical Reviews in Clinical Laboratory Sciences·Prasenjit MitraPraveen Sharma
Jan 5, 2018·Iranian Journal of Basic Medical Sciences·Sri Agus Sudjarwo Koerniasari
Feb 14, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yasmina M Abd-ElhakimSabry M Abd-Elmotal
Dec 21, 2018·Journal of Pharmacy & Bioallied Sciences·Ayon BhattacharyaSanjay Kumar
Aug 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aliyat O NafiuOluwole O Odujoko
Aug 16, 2019·International Journal of Environmental Research and Public Health·Al Omar S YousefRami B Kassab
Nov 22, 2019·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Eman E El ShanawanyEman H Abdel-Rahman
Dec 12, 2019·Environmental Science and Pollution Research International·Gadah AlbasherAhmed E Abdel Moneim
Mar 27, 2020·Human & Experimental Toxicology·R S BatyR B Kassab

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Jul 5, 2021·Environmental Science and Pollution Research International·Mohamed SeifZaizhao Wang

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