Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams

Journal of Animal Science
M Y El-MokademA M Yassen

Abstract

The objective of this study was to evaluate the reproductive toxicity of gossypol and the possible counteracting effect of selenium supplementation in rams. Twenty-five mature crossbred (Barki × Rahamni) rams were randomly divided into 5 equal groups. The first group served as a control (no gossypol in diet). The second and third groups received diets containing free gossypol of 9 and 14 mg·kg(-1) BW·d(-1)(low level and high level of gossypol), respectively. The fourth and fifth groups received the same diets given to the second and third groups, respectively, with an oral administration of 1 mg selenium (as sodium selenite) daily for each animal. Results showed reductions in ejaculate volume (P = 0.028), percentage of dead sperm (P = 0.003), total functional sperm fraction (P < 0.001), and blood serum concentration of testosterone (P < 0.001) in the presence of both levels of gossypol inclusion. Furthermore, high level of gossypol reduced forward motility (P < 0.001) and semen initial fructose concentration (P = 0.002) and increased abnormal-head sperm (P = 0.003) and blood serum concentration of triiodothyronine (P = 0.006). Regardless of selenium supplementation, increasing level of free gossypol in diet resulted in a signif...Continue Reading

References

May 1, 1979·Biology of Reproduction·A S WuP R Cheeke
Feb 1, 1990·Biological Trace Element Research·J AasethY Thomassen
Feb 1, 1990·Journal of Child Language·V Youssef
Apr 1, 1990·Contraception·Y C LinY Rikihisa
Jan 1, 1989·The International Journal of Biochemistry·H BreitbartL Nass-Arden
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Mar 1, 1984·Biology of Reproduction·J G Alvarez, B T Storey
Jan 30, 1984·Biochemical and Biophysical Research Communications·A de PeysterM T Smith
Feb 1, 1994·Journal of Animal Science·C C ChaseR D Randel
Oct 1, 1995·Diabetes/metabolism Reviews·P S Van DamB Bravenboer
Mar 1, 1996·Journal of Reproduction and Fertility·D BehneA Kyriakopoulos
Apr 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R Barhoumi, R C Burghardt
Oct 7, 1997·Biology of Reproduction·C BrocasP J Hansen
Jan 1, 1996·Reviews of Reproduction·D S Irvine
May 23, 1998·Molecular Human Reproduction·A A ZalataF H Comhaire
Aug 12, 1998·British Journal of Urology·R ScottJ Dixon
Dec 18, 1998·Journal of Animal Science·J Velasquez-PereiraN S Wilkinson
Nov 24, 1999·Animal Reproduction Science·J ThundathilA D Barth
Apr 4, 2000·British Medical Bulletin·J R Arthur, G J Beckett
May 8, 2000·Theriogenology·P J ChenowethR E Larsen
Nov 30, 2000·Theriogenology·J ThundathilR J Mapletoft
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·S R Stapleton
Apr 11, 2001·Small Ruminant Research : the Journal of the International Goat Association·M J. RockG E. Carstens
Sep 1, 2001·Animal Reproduction Science·J ThundathilC Barros
Mar 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Li YouRajagopal Sriperumbudur
Mar 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T Takamura-EnyaK Wakabayashi
Mar 24, 2004·Theriogenology·Magdy E HassanDavid J Schaeffer

❮ Previous
Next ❯

Citations

Jun 5, 2014·TheScientificWorldJournal·Ivana Cristina N GadelhaBenito Soto-Blanco
Dec 30, 2014·TheScientificWorldJournal·Ivana Cristina Nunes GadelhaBenito Soto-Blanco
Apr 22, 2016·Tropical Animal Health and Production·Antônio Carlos Lopes CâmaraBenito Soto-Blanco
Mar 15, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nayanna Brunna da Silva FonsecaBenito Soto-Blanco
Dec 18, 2019·Environmental Science and Pollution Research International·Pushpa Rani GuvvalaSellappan Selvaraju
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Samar R SalehDoaa A Ghareeb
Jul 7, 2019·Theriogenology·M M Mojapelo, K C Lehloenya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.