PMID: 15238369Jul 9, 2004Paper

ALLHAT: setting the record straight

Annals of Internal Medicine
Barry R DavisALLHAT Collaborative Research Group

Abstract

The findings of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) have generated worldwide reaction from clinicians and researchers, including a recent commentary in this journal. Such response was expected for a trial of ALLHAT's size and scope, especially since its results challenged some widely held beliefs. This paper reviews key aspects of the ALLHAT design, analyses, findings, and conclusions to provide a perspective on the commentary about the trial's results and implications for clinical practice. Several of the most frequent comments regarding the study's results are addressed, particularly with respect to heart failure and diabetes outcomes. Responses to these comments reinforce the investigators' original conclusion that thiazide-type diuretics should remain the preferred first-step drug class for treating hypertension and should generally be a part of any multidrug regimen.

Citations

May 13, 2009·Archives of Internal Medicine·Jackson T WrightUNKNOWN ALLHAT Collaborative Research Group
May 26, 2010·Archives of Internal Medicine·Randall S StaffordUNKNOWN ALLHAT Collaborative Research Group
Jul 23, 2005·Current Heart Failure Reports·Thomas W Wallace, Mark H Drazner
Nov 8, 2006·Current Hypertension Reports·Keith C Ferdinand, Myra A Kleinpeter
Jan 26, 2007·Nature Clinical Practice. Nephrology·Lee A HebertChristopher J Hebert
Dec 3, 2009·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Kerem ShuvalShmuel Reis
Apr 25, 2007·Hypertension·Timothy L ReudelhuberPatrick Delafontaine
Jul 10, 2009·Clinical Trials : Journal of the Society for Clinical Trials·L Kay Bartholomew Allhat Collaborative Research Group
Sep 29, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Frans H H Leenen
Apr 2, 2011·Indian Journal of Pharmacology·Bhaswat S Chakraborty
Nov 30, 2007·Kidney International·B H Rovin, L A Hebert
Apr 29, 2005·The Journal of Clinical Hypertension·William J Elliott, Armin Bandari
Sep 16, 2009·The Journal of Clinical Hypertension·Richard H GrimmUNKNOWN ALLHAT Collaborative Research Group
Dec 19, 2006·American Heart Journal·Paula T EinhornUNKNOWN ALLHAT Collaborative Research Group
Dec 6, 2005·Cerebrovascular Diseases·Antonio C Gil-Núñez, José Vivancos-Mora
Dec 7, 2005·The Journal of Clinical Hypertension·Domenic A Sica
May 20, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Alan J Zillich, Stuart T Haines
Jun 4, 2010·Current Opinion in Cardiology·Paula T EinhornUNKNOWN ALLHAT Cooperative Research Group
Jun 11, 2010·Current Opinion in Cardiology·William J Elliott
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Antonio Salvetti, Lorenzo Ghiadoni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Current Hypertension Reports
Henry A PunziTrinity Hypertension Research Institute
Journal of the Renin-angiotensin-aldosterone System : JRAAS
Cristina Sierra, Luis M Ruilope
JAMA : the Journal of the American Medical Association
ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
The New England Journal of Medicine
Lindon M H WingSecond Australian National Blood Pressure Study Group
© 2022 Meta ULC. All rights reserved