Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway

European Journal of Pharmacology
Chang-Ling LiChun-Mei Ma

Abstract

As diabetic macroangiopathy is becoming increasingly prevalent, it is urgent to explore preventive and therapeutic drugs and study the mechanism. Diabetic mice were induced by intraperitoneal injection of streptozotocin (STZ)for five consecutive days. Diabetic mice were divided into diabetic and allicin groups. After sacrifice, frozen aortic root sections were immunohistochemically stained for nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammation cytokine-tumor necrosis factor α (TNF-α), and the remaining aortic tissues were analyzed by Western blot for the expression of proinflammation genes. In vitro, Nrf2 and inflammatory relative protein expression levels in Human Umbilical Vein Endothelial Cells (HUVECs) were examined. HUVECs proliferation and apoptosis were measured. TNF-α expression was increased in diabetic group compared to that in control group; this effect was alleviated in allicin-treated mice. Inflammation relative protein expression of Vascular Cell Adhesion Molecule 1(VCAM-1), Matrix metalloproteinase 2 (MMP-2), Inducible Nitric Oxide Synthase (iNOS), and monocyte chemotactic protein 1 (MCP-1) was higher in the diabetic group than in the control group; however, allicin treatment inhibited these diab...Continue Reading

Citations

Dec 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yonghui YinXiaoli Li
Apr 25, 2021·Phytotherapy Research : PTR·Abu Mohammad SyedBidya Dhar Sahu
Jun 14, 2021·Environmental Science and Pollution Research International·Hanan A EdresMohamed S Elfeky

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