Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

Oncology Reports
Jae Hun ChaWon Ho Cho

Abstract

Allicin, the main flavor compound in garlic, has anti-carcinogenic activities in a range of cancer cells, however, the underlying molecular mechanisms are not completely understood. This study examined the effect of allicin on the cell viability of U87MG human glioma cells along with its molecular mechanisms of induction of cell death. Apoptosis was determined by TUNEL and Hoechst 33258 staining as well as by western blot analysis. Allicin inhibited the cell viability of U87MG human glioma cells in a dose- and time-dependent manner. Allicin-induced inhibition of cell viability was due to apoptosis of cells. The mechanisms of apoptosis were found to involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems. These results suggest that allicin can serve as a novel chemotherapeutic candidate for the treatment of glioblastoma multiforme.

Citations

Aug 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan BorlinghausAlan J Slusarenko
Jul 20, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Esma YagdiMarc Diederich
Feb 16, 2013·Biochemical and Biophysical Research Communications·Robin I DeWaltSusan A McDowell
Mar 21, 2015·PloS One·Hussein AkilJean-Claude Lecron
Jan 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carole Nicco, Frédéric Batteux
Sep 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Murugan Sesha SubramanianNarcisse Joseph
Apr 23, 2020·International Journal of Molecular Sciences·Jose Manuel Perez-OrtizFrancisco Javier Redondo-Calvo
Sep 5, 2020·Cancer Management and Research·Zelin YangJian Lin
Jan 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adrian Bogdan ȚiguMarcel Pârvu
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan BorlinghausAlan J Slusarenko
May 15, 2021·Frontiers in Oncology·Mahshad SarvizadehHamed Mirzaei
Aug 14, 2020·Journal of Natural Products·Chad R SchultzAndré S Bachmann
Aug 24, 2021·Oxidative Medicine and Cellular Longevity·Dionysia TheofylaktouAlexandros G Georgakilas

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