Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases

Life Sciences
Feres José Mocayar MarónWalter Manucha

Abstract

According to investigations in phytomedicine and ethnopharmacology, the therapeutic properties of garlic (Allium sativum) have been described by ancestral cultures. Notwithstanding, it is of particular concern to elucidate the molecular mechanisms underlying this millenary empirical knowledge. Allicin (S-allyl prop-2-ene-1-sulfinothioate), a thioester of sulfenic acid, is one of the main bioactive compounds present in garlic, and it is responsible for the particular aroma of the spice. The pharmacological attributes of allicin integrate a broad spectrum of properties (e.g., anti-inflammatory, immunomodulatory, antibiotic, antifungal, antiparasitic, antioxidant, nephroprotective, neuroprotective, cardioprotective, and anti-tumoral activities, among others). The primary goal of the present article is to review and clarify the common molecular mechanisms by which allicin and its derivates molecules may perform its therapeutic effects on cardiovascular diseases and neuroinflammatory processes. The intricate interface connecting the cardiovascular and nervous systems suggests that the impairment of one organ could contribute to the dysfunction of the other. Allicin might target the cornerstone of the pathological processes underlyin...Continue Reading

Citations

Dec 10, 2020·Clinical and Translational Allergy·Jean BousquetUNKNOWN ARIA group
Jul 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cun LiuChanggang Sun
Apr 16, 2021·Frontiers in Physiology·Yating ChenJiancheng Zhang
Jun 19, 2021·Acta Parasitologica·Chuanchuan LiuRi-Li Ge
Jun 14, 2021·Environmental Science and Pollution Research International·Hanan A EdresMohamed S Elfeky
Jun 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marcia RibeiroDenise Mafra
Aug 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yungang ShanLimin Jin

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