PMID: 6967215May 1, 1980Paper

Alloantigen-induced T-cell proliferation: Lyt phenotype of responding cells and blocking of proliferation by Lyt antisera

Proceedings of the National Academy of Sciences of the United States of America
E NakayamaL J Old


Cytotoxic T cells of the mouse express Lyt-1 as well as Lyt-2 and -3 on their surface, and T-cell cytotoxicity can be blocked by Lyt-2 and Lyt-3 (but not Lyt-1) antisera in the absence of added complement [Nakayama, E., Shiku, H., Stockert, E., Oettgen, H. F. & Old, L. J. (1979) Proc. Natl. Acad. Sci. USA 76, 1977-1981]. This analysis has now been extended to the study of the Lyt phenotype of T cells responding to alloantigens, concanavalin A (Con A), and phytohemagglutinin (PHA) and the effect of Lyt antibody on T-cell proliferation and the generation of H-2-specific killer T cells. H-2 (D/K and I), Con A, and PHA stimulation was abolished by pretreating responding cell populations with Lyt-1 antiserum and complement. Pretreatment with Lyt-2 or -3 antiserum and complement did not decrease alloantigen or Con A stimulation but did abolish PHA stimulation. Cytotoxic cells were not generated in H-2 alloantigen-primed cultures pretreated with Lyt-1, -2, or -3 antiserum and complement. When responding cells were cultured with Lyt antiserum in the absence of added complement, Lyt-2 or -3 antiserum (but not Lyt-1 antiserum) blocked alloantigen-induced proliferation and delayed generation of killer cells. Under similar conditions, Con ...Continue Reading


Oct 1, 1976·The Journal of Experimental Medicine·H ShikuH F Oettgen
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Sep 1, 1978·The Journal of Experimental Medicine·F H Bach, B J Alter
Jul 14, 1977·Nature·S Gillis, K A Smith
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P J WettsteinJ A Frelinger
Jan 1, 1977·Annual Review of Genetics·L J Old, E Stockert
Aug 5, 1976·Nature·P C BeverleyI McKenzie
Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old

❮ Previous
Next ❯


Jan 1, 1985·Human Genetics·G BrunsL A Herzenberg
Oct 16, 1999·Scandinavian Journal of Immunology·M UlanovaL A Hanson
Jul 10, 2001·Psychiatry and Clinical Neurosciences·Y MoriN Tashiro
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G JayL J Old
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P KavathasJ R Parnes
Aug 1, 1996·The Journal of Experimental Medicine·M AsanoS Sakaguchi
Sep 12, 2002·Microbiology and Immunology·Sanda WinEiichi Nakayama
Feb 1, 1994·Journal of Neuroimmunology·C G McAllisterK A Perkins
Oct 1, 1983·Cellular Immunology·J A Harp, S J Ewald
Sep 1, 1982·Immunology Today·R J Hodes
Jan 1, 1993·Transplant Immunology·A UenakaE Nakayama
Jan 1, 1982·Immunological Reviews·J A Ledbetter, W E Seaman
Sep 1, 1983·Scandinavian Journal of Immunology·G PoborA Coutinho
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akiko UenakaEiichi Nakayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.