PMID: 6967215May 1, 1980Paper

Alloantigen-induced T-cell proliferation: Lyt phenotype of responding cells and blocking of proliferation by Lyt antisera

Proceedings of the National Academy of Sciences of the United States of America
E NakayamaL J Old

Abstract

Cytotoxic T cells of the mouse express Lyt-1 as well as Lyt-2 and -3 on their surface, and T-cell cytotoxicity can be blocked by Lyt-2 and Lyt-3 (but not Lyt-1) antisera in the absence of added complement [Nakayama, E., Shiku, H., Stockert, E., Oettgen, H. F. & Old, L. J. (1979) Proc. Natl. Acad. Sci. USA 76, 1977-1981]. This analysis has now been extended to the study of the Lyt phenotype of T cells responding to alloantigens, concanavalin A (Con A), and phytohemagglutinin (PHA) and the effect of Lyt antibody on T-cell proliferation and the generation of H-2-specific killer T cells. H-2 (D/K and I), Con A, and PHA stimulation was abolished by pretreating responding cell populations with Lyt-1 antiserum and complement. Pretreatment with Lyt-2 or -3 antiserum and complement did not decrease alloantigen or Con A stimulation but did abolish PHA stimulation. Cytotoxic cells were not generated in H-2 alloantigen-primed cultures pretreated with Lyt-1, -2, or -3 antiserum and complement. When responding cells were cultured with Lyt antiserum in the absence of added complement, Lyt-2 or -3 antiserum (but not Lyt-1 antiserum) blocked alloantigen-induced proliferation and delayed generation of killer cells. Under similar conditions, Con ...Continue Reading

References

Oct 1, 1976·The Journal of Experimental Medicine·H ShikuH F Oettgen
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Sep 1, 1978·The Journal of Experimental Medicine·F H Bach, B J Alter
Jul 14, 1977·Nature·S Gillis, K A Smith
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P J WettsteinJ A Frelinger
Jan 1, 1977·Annual Review of Genetics·L J Old, E Stockert
Aug 5, 1976·Nature·P C BeverleyI McKenzie
Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old

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Citations

Jan 1, 1985·Human Genetics·G BrunsL A Herzenberg
Oct 16, 1999·Scandinavian Journal of Immunology·M UlanovaL A Hanson
Jul 10, 2001·Psychiatry and Clinical Neurosciences·Y MoriN Tashiro
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G JayL J Old
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P KavathasJ R Parnes
Aug 1, 1996·The Journal of Experimental Medicine·M AsanoS Sakaguchi
Sep 12, 2002·Microbiology and Immunology·Sanda WinEiichi Nakayama
Feb 1, 1994·Journal of Neuroimmunology·C G McAllisterK A Perkins
Oct 1, 1983·Cellular Immunology·J A Harp, S J Ewald
Sep 1, 1982·Immunology Today·R J Hodes
Jan 1, 1993·Transplant Immunology·A UenakaE Nakayama
Jan 1, 1982·Immunological Reviews·J A Ledbetter, W E Seaman
Sep 1, 1983·Scandinavian Journal of Immunology·G PoborA Coutinho
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akiko UenakaEiichi Nakayama

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