PMID: 6974692Jan 1, 1981Paper

Alloantigens expressed on activated human T cells different from HLA-A, B, C, and DR antigens

Immunogenetics
M Gerbase de LimaJ Dausset

Abstract

This study investigates alloantisera containing antibodies directed against antigens which are expressed on alloactivated human T lymphocytes but are absent on resting T and B cells. Among 39 defined anti-HLA-DR sera from multiparous women we found six sera giving positive reactions (more than 25 percent cytotoxicity) on in vitro alloactivated T cells, though negative reactions with resting B or T cells from the donors of either the responding or stimulating cell populations used for alloactivation. Two such sera were submitted to absorption and elution studies. Absorption of these sera with activated T cells did not remove the anti-HLA-DR activity. Furthermore, the antibodies eluted from activated T cells did not react with B cells but were positive only on activated T cells. In addition, we absorbed the sera with B cells and observed that they remained positive on activated T cells. The positive reactions do not seem to be due to either the passive acquisition of antigens from the stimulating population or to low levels of HLA-specific antibodies. As one of the sera we studied intensively gave clear positive and negative reactions on a panel of activated T lymphocytes, we believe it may recognize an antigen of an allogeneic s...Continue Reading

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Citations

Sep 1, 1986·Human Immunology·R FauchetD J Charron
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P PaulD Cohen
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y ShimizuR DeMars
Aug 1, 1987·Journal of Immunogenetics·T CrepaldiP Richiardi
Apr 1, 1983·Arthritis and Rheumatism·R P SearlesJ S Goodwin
Aug 1, 1987·Tissue Antigens·D PeruccioP Richiardi

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