PMID: 6167547Sep 1, 1980Paper

Alloantigens of the human T (HT) genetic region of the HLA linkage group

Human Immunology
E GazitE J Yunis

Abstract

This article describes an approach that characterizes alloantisera reactive with new determinants on mitogen-activated human lymphocytes. These markers, which are tentatively called HT-antigens, are different from the classical HLA-A,C,C, and DR antigens but are associated with beta 2-microglobulin. Several alloantisera were tested extensively on lymphocytes that were treated initially with an antigen-blocking technique using turkey anti-beta 2-microglobulin and turkey anti-p29,34 sera or with an antigen-modulation technique using xeno- and alloantisera. It was concluded that these tested antisera recognized three different determinants (HT1, HT3, and HT (1 + 3) that appeared to segregate with the HLA-A locus of the HLA haplotype. HT antigens may be analogous to the murine TL-Qa antigens since HT antigens are associated with beta 2-microglobulin, are generally related to the HLA region, and are expressed on mitogen activated T cells but not on resting T cells.

References

Nov 1, 1978·The Journal of Experimental Medicine·R L EvansS F Schlossman
Jul 1, 1979·The Journal of Experimental Medicine·G J HämmerlingL Flaherty
Jan 1, 1974·Contemporary Topics in Molecular Immunology·M J Crumpton, D Snary

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Citations

Apr 1, 1982·Human Immunology·A van LeeuwenJ J van Rood
Jan 1, 1983·Human Immunology·P G LerchC Terhorst
Sep 1, 1986·Human Immunology·R FauchetD J Charron
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M MalissenB R Jordan
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P PaulD Cohen
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y ShimizuR DeMars
Jun 1, 1990·American Journal of Reproductive Immunology : AJRI·A InnesG R Catto
Dec 1, 1983·Immunobiology·J Neppert, C Mueller-Eckhardt
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·C M Zmijewski
Oct 1, 1994·Immunology and Cell Biology·M T DorakM Worwood

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