PMID: 9450812Feb 5, 1998Paper

Allogeneic bone marrow transplantation with T-cell-depleted marrow grafts for patients with poor-risk relapsed low-grade non-Hodgkin's lymphoma

British Journal of Haematology
C M MandigersTh De Witte

Abstract

We present the clinical results of allogeneic bone marrow transplantation (BMT) with T-cell-depleted grafts from HLA-matched sibling donors in patients with poor-risk relapsed low-grade non-Hodgkin's lymphoma (NHL). Poor risk was defined as relapse within 12 months after or progression during prior treatment. The conditioning regimen consisted of cyclophosphamide and total-body irradiation with or without additional idarubicin. Donor marrow was depleted of T lymphocytes using counterflow centrifugation. Post-BMT prophylaxis of graft-versus-host disease (GvHD) consisted of cyclosporine A. 15 patients with a median age of 47 years (range 30-57) were transplanted. All patients engrafted. After a median follow-up of 36 months (range 9-78), 10 patients were alive and in complete remission (CR). Two of them had relapsed after BMT but re-entered CR following infusions of leucocytes from the original bone marrow donor. Five patients died; causes of death were cardiomyopathy (n = 1), chronic GvHD (n = 1) and infection during chronic GvHD (n = 3). We conclude that allogeneic T-cell-depleted bone marrow transplantation is an efficacious treatment for patients with poor-risk relapsed low-grade NHL. Infusions of donor leucocytes reinduced C...Continue Reading

References

Jun 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J WeisdorfM M Oken
Jan 6, 1990·Lancet·V S GharpureS T Durrant
Aug 1, 1989·International Journal of Colorectal Disease·J C SarlesS Olivier
Dec 1, 1987·British Journal of Haematology·R P GaleJ H Kersey
May 1, 1984·Annals of Internal Medicine·D L LongoV T DeVita
Aug 1, 1980·The American Journal of Medicine·H M ShulmanE D Thomas
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D Cheson
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K W van BesienR Nath
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W JohnsonT A Lister
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J P MeijerinkE J Mensink
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H C SchoutenA H Goldstone
Mar 4, 1993·The New England Journal of Medicine·N A KernanJ McCullough
May 1, 1996·Archives of Disease in Childhood·K NysomH Hertz
Dec 1, 1996·Bone Marrow Transplantation·J GabarreJ L Binet
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R H CollinsJ Nemunaitis
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J BiermanJ O Armitage
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Z S PavleticA Kessinger

❮ Previous
Next ❯

Citations

Aug 10, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Marek Jakóbisiak, Jakub Gołab
Jul 5, 2003·Experimental Hematology·Imad A Tabbara, Richard M Ingram
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·A D MurthaR Hoppe
Jun 23, 2000·Critical Reviews in Oncology/hematology·P SoubeyranH Eghbali
Feb 22, 2002·Critical Reviews in Oncology/hematology·Nicolas MounierChristian Gisselbrecht
Sep 10, 2003·Seminars in Cancer Biology·Jürgen Finke
Sep 14, 2001·Current Opinion in Oncology·J G Berdeja, I W Flinn
Jul 10, 1999·Current Opinion in Hematology·R G Bociek, J O Armitage
Jan 11, 2005·British Journal of Haematology·Karl S PeggsDavid C Linch
May 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frank HeinzelmannMartin Weinmann
Jun 7, 2011·Blood Reviews·Koen van Besien
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip J BiermanUNKNOWN Lymphoma Working Committee of the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow
Oct 19, 2004·Bone Marrow Transplantation·W W TseK Van Besien
May 17, 2005·Bone Marrow Transplantation·B W Butcher, R H Collins
Jul 21, 2011·British Journal of Haematology·Jane StevensSimon Joel
Oct 18, 2002·Blood·José A Pérez-SimónUNKNOWN Spanish and United Kingdom Collaborative Groups for Nonmyeloablative Transplantation
Sep 10, 2008·Blood·Koen van Besien, Parameswaran Hari
Jun 18, 2002·The Oncologist·Peter McLaughlin
Apr 20, 2002·Cancer Control : Journal of the Moffitt Cancer Center·Leo Luznik, Ephraim J Fuchs

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.