Allogeneic bone marrow transplantation with reduced intensity conditioning for chronic granulomatous disease complicated by invasive Aspergillus infection

Pediatric Blood & Cancer
Jairam SastryPeter J Shaw

Abstract

Chronic granulomatous disease (CGD) is a rare disorder characterized by recurrent infections, often resulting in impaired quality of life and death. Allogeneic BMT provides a definitive cure for CGD, but carries a significant risk of mortality and morbidity. The risk is higher for those who have invasive fungal infection prior to transplant. Reduced intensity conditioning (RIC) is associated with less toxicity from the conditioning agents and may provide an alternative option for all non-malignant diseases. We report a case of successful allogeneic BMT after RIC for a case of X-linked CGD complicated by severe invasive aspergillosis (IA).

References

Feb 21, 1991·The New England Journal of Medicine·UNKNOWN International Chronic Granulomatous Disease Cooperative Study Group
Sep 1, 1990·The Journal of Infectious Diseases·D M MargolisJ I Gallin
Sep 1, 1990·Archives of Disease in Childhood·A FinnR J Levinsky
May 3, 2000·Clinical and Experimental Immunology·C M CaleD Goldblatt
Jan 27, 2004·Bone Marrow Transplantation·J SastryP J Shaw
Jul 15, 2004·Blood·Balázs K RadaErzsébet Ligeti
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Balázs K RadaErzsébet Ligeti

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Citations

Sep 23, 2008·Immunologic Research·Elizabeth M Kang, Harry L Malech
May 30, 2008·Seminars in Immunopathology·Marie José Stasia, Xing Jun Li
Nov 15, 2007·The Journal of Nervous and Mental Disease·Catherine M CahillGin S Malhi
Jun 8, 2021·The Pediatric Infectious Disease Journal·Cinzia DedieuHorst von Bernuth

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