Allogeneic Cellular Therapy in a Mature Tooth with Apical Periodontitis and Accidental Root Perforation: A Case Report

Journal of Endodontics
Claudia Brizuela CorderoMaroun Khoury

Abstract

Cell therapy in regenerative endodontics introduces an alternative option to classic treatment strategies for complex endodontic cases. The aim of this case report was to describe cell-based therapy using allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) encapsulated in a bioscaffold for a complex case of a mature permanent tooth with apical periodontitis and accidental root perforation. A healthy 19-year-old man undergoing orthodontic treatment was referred for endodontic treatment in tooth #7; he was diagnosed with apical periodontitis during a previously initiated treatment associated with accidental perforation of the radicular cervical third. The root perforation was sealed with glass ionomer and composite resin, and the root canal was instrumented, disinfected, and dressed with calcium hydroxide. After 3 weeks, allogeneic UC-MSCs were encapsulated in platelet-poor plasma and then implanted into the root canal, and Biodentine (Septodont, Saint-Maur-des-Fosses, France) was placed below the cementoenamel junction. Finally, the tooth was restored with composite resin. Follow-up examinations were performed 6 months and 1 year later. The examinations included periapical radiography, cone-beam computed tomographic imagi...Continue Reading

References

Feb 1, 1986·Endodontics & Dental Traumatology·D OrstavikH M Eriksen
Jun 3, 2005·Journal of Public Health Dentistry·Daniel J CaplanB Alex White
Oct 21, 2006·Stem Cells·Sercin KarahuseyinogluAlp Can
Oct 22, 2008·Journal of Endodontics·Carlos EstrelaJesus Djalma Pécora
Mar 1, 2009·International Journal of Oral Science·Li PengXue-dong Zhou
Jun 14, 2013·Stem Cells Translational Medicine·Koichiro IoharaMisako Nakashima
Jun 1, 2014·Journal of Dental Research·G T-J Huang, F Garcia-Godoy
Sep 10, 2014·Journal of Dental Research·M T P AlbuquerqueM C Bottino
Jul 22, 2015·Journal of Dental Research·V ChrepaA Diogenes
Jul 25, 2015·Tissue Antigens·R Al-Daccak, D Charron
Sep 15, 2015·Journal of Periodontology·Constanza E MartínezPatricio C Smith
Mar 28, 2016·The Journal of the American Dental Association·Anibal DiogenesKenneth M Hargreaves
May 20, 2018·International Endodontic Journal·S G KimB Kahler
Sep 30, 2018·Progress in Biomaterials·Hengameh BakhtiarP M H Dummer
Feb 8, 2019·Journal of Tissue Engineering·Chanyong JungMinju Song
Feb 9, 2019·The Japanese Dental Science Review·Takahiko MorotomiChiaki Kitamura
Jun 25, 2019·International Endodontic Journal·K M Fawzy El-SayedF Schwendicke

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