PMID: 2095193Jul 1, 1990Paper

Allogeneic cultured epidermal grafts heal chronic ulcers although they do not remain as proved by DNA analysis

Journal of Dermatological Science
D RoseeuwY Vandenberghe

Abstract

To investigate whether allogeneic cultured keratinocytes are rejected or not, and to find out how beneficial their effect on wound healing could be, patients with chronic ulcers were grafted with allogeneic cultured human keratinocytes. In order to examine the epidermal origin of the healed wound, DNA analysis was performed and compared to donor and recipient blood-cell DNA. Healing was observed in 84% of the grafted ulcers by granulation tissue stimulation and would edge effect. In little time 60% of the grafted chronic ulcers healed completely. Although no rejection was observed, DNA analysis revealed that the grafted allogeneic keratinocytes were finally replaced by the patient's own epidermis. This study confirmed that cultured allogeneic keratinocytes that have been grafted on ulcers, play an important role in the wound healing process.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L M KunkelJ M Rary
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H GreenJ Thomas
Feb 1, 1979·Transplantation·M JonkerJ J van Rood
Nov 1, 1987·The British Journal of Dermatology·I M LeighT J Phillips
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M EisingerR B Flick
Jan 1, 1986·Archives of Dermatological Research·J ThivoletG Mauduit
Jun 1, 1988·Journal of the American Academy of Dermatology·J M ClancyP L Levick
Jun 1, 1987·Burns, Including Thermal Injury·A EldadB Gusterson
Mar 1, 1986·Journal of the American Academy of Dermatology·J M HeftonD M Carter
Mar 1, 1984·The British Journal of Dermatology·R L BarnhillT J Ryan
Mar 1, 1984·Archives of Surgery·B A Pruitt, N S Levine

❮ Previous
Next ❯

Citations

Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D RoseeuwV Rogiers
Apr 29, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Peggy L ChernChristopher J Arpey
Apr 15, 2003·The Journal of Dermatology·Yuji ShirakataKoji Hashimoto
Nov 12, 2005·Journal of Plant Research·Paul Galland, Alexander Pazur
Jul 6, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Giovanni MostiLuca Bastiani
Jan 1, 1994·The Journal of Investigative Dermatology·S T Boyce

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Annales de chirurgie de la main et du membre supérieur : organe officiel des sociétés de chirurgie de la main = Annals of hand and upper limb surgery
G L CampiglioG Rafanelli
Dermatology : International Journal for Clinical and Investigative Dermatology
D RoseeuwJ Ramet
© 2021 Meta ULC. All rights reserved