Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia?

Journal of Translational Medicine
Michael P MurphyNeil H Riordan

Abstract

Critical limb ischemia (CLI) is an advanced form of peripheral artery disease which is responsible for approximately 100,000 amputations per year in the US. Trials to date have reported clinical improvement and reduced need for amputation in CLI patients receiving autologous bone marrow or mobilized peripheral blood stem cells for stimulation of angiogenesis. While such treatments are currently entering Phase III trials, practical and scientific pitfalls will limit widespread implementation if efficacy is proven. Hurdles to be overcome include: a) reduced angiogenic potential of autologous cells in aged patients with cardiovascular risk factors; b) invasiveness/adverse effects of bone marrow extraction and G-CSF mobilization, respectively; and c) need for on-site cellular manipulation. The Endometrial Regenerative Cell (ERC) is a mesenchymal-like stem cell derived from the menstrual blood that is believed to be associated with endometrial angiogenesis. We discuss the possibility of using allogeneic ERCs as an "off the shelf" treatment for CLI based on the following properties: a) High levels of growth factors and matrix metalloprotease production; b) Ability to inhibits inflammatory responses and lack of immunogenicity; and c) ...Continue Reading

References

May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·S OrtegaC Basilico
Mar 6, 1999·Annals of Internal Medicine·R M Schainfeld, J M Isner
Jan 22, 2000·Journal of Vascular Surgery·A D Whittemore
May 8, 2000·Zeitschrift für Kardiologie·A Helisch, W Schaper
Jun 6, 2000·Critical Reviews in Oncology/hematology·P GerwinsL Claesson-Welsh
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Nov 24, 2001·Molecular Human Reproduction·J M García-PachecoE G Olivares
Sep 21, 2002·Lancet·Eriko Tateishi-YuyamaUNKNOWN Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ken HirataKimikazu Hamano
Oct 25, 2002·Redox Report : Communications in Free Radical Research·Reida Menshawe El OakleySai-Kiang Lim
Dec 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kai-Michael ScheuflerDieter Marme
Jul 9, 2004·JAMA : the Journal of the American Medical Association·Hugh S Taylor
Aug 21, 2004·The Journal of Physiology·Malgorzata MilkiewiczStuart Egginton
Oct 16, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Koji YamamotoToyoaki Murohara
Apr 5, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kevin McDonnellAnton Wellstein
Jun 17, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katri PajusolaKari Alitalo
Oct 8, 2005·Angiogenesis·Jane E Girling, Peter A W Rogers
Nov 5, 2005·Stem Cells·Gina C Schatteman, Ning Ma
Apr 1, 2006·Circulation Research·Kaoru TatenoIssei Komuro
Oct 21, 2006·Current Opinion in Hematology·Armand Keating
Dec 5, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L NorgrenKenneth Rosenfield
Jan 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiro KajiguchiToyoaki Murohara

❮ Previous
Next ❯

Citations

Sep 2, 2011·Calcified Tissue International·Kaarthik S ChandrasekharJiliang Li
Aug 1, 2012·Reviews in Endocrine & Metabolic Disorders·Caroline E GargettLouie Ye
Jan 16, 2010·ILAR Journal·Valerie L Joers, Marina E Emborg
Jul 16, 2010·Molecular Human Reproduction·Caroline E Gargett, Hirotaka Masuda
Apr 23, 2009·Cardiology in Review·Steve Attanasio, Jeffrey Snell
Apr 27, 2013·Circulation Research·Zankhana Raval, Douglas W Losordo
Oct 9, 2012·Journal of Translational Medicine·Huan WangDavid F Stroncek
Mar 21, 2013·Journal of Translational Medicine·Leo BockeriaAmit N Patel
Feb 24, 2009·Journal of Translational Medicine·Zhaohui ZhongBoris Minev
Jun 23, 2009·Journal of Translational Medicine·Tatiana JazedjeMayana Zatz
Apr 20, 2010·International Archives of Medicine·Thomas E IchimNeil H Riordan
Aug 1, 2012·Stem Cell Research & Therapy·Aaron Liew, Timothy O'Brien
Aug 15, 2014·BioMed Research International·Jae Heon KimYun Seob Song
Aug 30, 2014·International Journal of Molecular Sciences·Naoki TajiriYuji Kaneko
Aug 13, 2013·Expert Opinion on Biological Therapy·Daniela UlrichCaroline E Gargett
Dec 6, 2014·Journal of Translational Medicine·Yongcheng LvHao Wang
Jan 30, 2016·Journal of Translational Medicine·Peng SunHao Wang
Jun 5, 2012·Fertility and Sterility·Caroline E Gargett, Louie Ye
Jul 15, 2009·Biomaterials·Golnaz KaroubiDavid W Courtman
Dec 23, 2008·Medical Hypotheses·Man-Jing ZhangKai-Hua Lu
Jul 11, 2013·Journal of Cellular and Molecular Medicine·Zhi JiangJian-an Wang
Dec 14, 2011·Journal of Biomedicine & Biotechnology·Maria Carolina O RodriguesCesar V Borlongan
Jun 19, 2013·Medical Hypotheses·Chun-Hua TuPing Zhang
May 5, 2012·Journal of Zhejiang University. Science. B·Julie Allickson, Charlie Xiang
Apr 30, 2011·Journal of Zhejiang University. Science. B·Jian LinCharlie Xiang
Nov 6, 2013·Journal of Zhejiang University. Science. B·Xiao-zhou MouCharlie Xiang
Jun 1, 2012·Interventional Medicine & Applied Science·Maria Carolina O RodriguesCesar V Borlongan
Jun 8, 2011·Neuroscience and Biobehavioral Reviews·Maria Carolina Oliveira RodriguesCesar V Borlongan
Jun 7, 2014·Frontiers in Immunology·Maroun KhouryFernando E Figueroa
Oct 30, 2016·Acta Biochimica Et Biophysica Sinica·Dongmei LaiCharlie Xiang
Aug 4, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Yanling ZhangSongying Zhang
Oct 25, 2016·Journal of Translational Medicine·Shanzheng LuHao Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
amputations
transfection
amputation
ELISA

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.