PMID: 9660232Jul 11, 1998Paper

Allogeneic fetal intestinal transplantation with FK506 immunosuppression

Journal of Pediatric Surgery
W J McBrideD W Vane

Abstract

Small intestinal transplantation remains a significant clinical problem. Allogeneic fetal intestinal (AFI) transplantation shows promise, particularly regarding procurement; however, no studiesto date have evaluated the potential success of true allogeneic loci implantation. The authors hypothesized that isolated segments of AFI could be heterotopically transplanted but would require immunosuppression to survive. Donor tissue was obtained from late-gestation Brown Norway rat fetuses with a histo-locus RTN and Fischer fetuses with a histo-locus RT1L. The recipients were adolescent male Fischer rats with a histo-locus RT1L. A 1.2-cm segment of fetal small bowel was implanted in the omentum of the recipient rat and allowed to mature for 5 weeks. Animals were then separated into five groups. Group A served as controls with syngeneic fetal intestinal (SFI) transplant. Group B received AFI with no immunosuppression; group C, AFI transplant with five days of FK506; group D, AFI with 10 days of FK506; and Group E, AFI with daily FK506 for the entire 5-week maturation period. Animals were killed on day 35. All animals gained weight over the maturation period. Groups B, C, and D had no viable transplant segments at day 35. Groups A and E...Continue Reading

References

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Citations

Mar 7, 2001·Journal of Neurotrauma·F Y FengS E Mackinnon
Oct 18, 2008·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Han HaishengLi Xin
Mar 12, 2002·The American Journal of Hospice & Palliative Care·T MoritaS Chihara

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