Allogeneic Hematopoietic Cell Transplantation Is an Effective Treatment for Blastic Plasmacytoid Dendritic Cell Neoplasm in First Complete Remission: Systematic Review and Meta-analysis

Clinical Lymphoma, Myeloma & Leukemia
M A Kharfan-DabajaA Kumar

Abstract

It is common practice to refer patients to transplantation centers for allogeneic hematopoietic cell transplantation (allo-HCT) for blastic plasmacytoid dendritic-cell neoplasm (BPDCN) despite lack of randomized controlled trials. We performed a systematic review to assess the totality of evidence pertaining to the efficacy of allo-HCT in BPDCN. We searched the Cochrane, PubMed, and Embase databases through January 5, 2018, for studies on allo-HCT for BPDCN. Two authors independently reviewed all references for inclusion and extracted data related to benefits (overall [OS] and progression-free/disease-free [PFS/DFS] survival) and harms (relapse and nonrelapse mortality) from included studies. When appropriate, data were pooled using random-effects model. Four studies (128 patients) were included in analysis. Pooled OS rate was 50% (95% confidence interval [CI], 41-59) for all patients. Among patients who underwent allografting whose disease was in first complete remission (CR1), pooled OS and PFS/DFS rates were 67% (95% CI, 52-80) and 53% (95% CI, 29-76), respectively. For patients who underwent allografting in > CR1, pooled OS and PFS/DFS rates were 7% (95% CI, 0-32) for both outcomes. Relapse rates were higher when reduced-in...Continue Reading

Citations

Dec 24, 2019·Blood Advances·Francine Garnache-OttouEric Deconinck
May 18, 2020·Current Oncology Reports·Nikolaos J Tsagarakis, Georgios Paterakis
Jan 5, 2021·International Journal of Hematology·Chan LiaoYong-Min Tang
Apr 28, 2020·Hematology/oncology Clinics of North America·Eric Deconinck
Mar 14, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Abraham S KanateMehdi Hamadani
Oct 14, 2021·Blood Advances·Caterina Giovanna ValentiniLivio Pagano

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