Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European Group for Blood and Marrow Transplantation analysis

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Johannes ScheteligPeter Dreger

Abstract

Patients with chronic lymphocytic leukemia (CLL) and 17p deletion (17p-) have a poor prognosis. Although allogeneic hematopoietic stem-cell transplantation (HCT) has the potential to cure patients with advanced CLL, it is not known whether this holds true for patients with 17p-CLL. Baseline data from patients, for whom information on the presence of 17p-CLL was available, were downloaded from the European Group for Blood and Marrow Transplantation database. Additional information on the course of CLL and follow-up was collected with a questionnaire. A total of 44 patients with 17p-CLL received allogeneic HCT between March 1995 and July 2006 from a matched sibling (n = 24) or an alternative donor (n = 20). 17p-CLL had been diagnosed by fluorescent in situ hybridization in 82% of patients and by conventional banding in 18% of patients. The median age was 54 years. Before HCT, a median of three lines of chemotherapy had been administered. At HCT, 53% of patients were in remission. Reduced-intensity conditioning was applied in 89% of patients. Acute, grade 2 to 4 graft-versus-host disease (GVHD) occurred in 43% of patients, and extensive chronic GVHD occurred in 53% of patients. At last follow-up, 19 patients were alive, with a med...Continue Reading

References

Jan 3, 2001·The New England Journal of Medicine·H DöhnerP Lichter
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J ScheteligUNKNOWN Cooperative German Transplant Study Group
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohamed L SorrorDavid G Maloney
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carol MorenoEmili Montserrat
Jul 27, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven Z PavleticClaudio Anasetti
Oct 6, 2005·Blood·Emili MontserratFrancesc Bosch
Nov 7, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jennifer R BrownEdwin P Alyea
Nov 17, 2006·Leukemia·P DregerUNKNOWN Chronic Leukemia Working Party of the EBMT
Mar 24, 2007·Nature Reviews. Molecular Cell Biology·Karen H Vousden, David P Lane
Nov 7, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter HillmenJiri Mayer

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Citations

Jan 27, 2009·Current Treatment Options in Oncology·Tahamtan AhmadiEdward Stadtmauer
Dec 15, 2010·Current Hematologic Malignancy Reports·Xavier C BadouxWilliam G Wierda
Jan 13, 2012·Current Hematologic Malignancy Reports·Leopold SellnerThorsten Zenz
Nov 29, 2012·Current Hematologic Malignancy Reports·L SellnerT Zenz
Aug 6, 2013·The Journal of Clinical Investigation·Ute E BurkhardtCatherine J Wu
Jan 18, 2011·Hematology·Alessandra Ferrajoli
Dec 10, 2013·Hematology·John G Gribben, John C Riches
Mar 17, 2011·Blood·Laurent SuttonUNKNOWN Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and Groupe Français d'étude de la Leucémie Lymphoï
Mar 8, 2012·Blood·Thorsten ZenzStephan Stilgenbauer
May 2, 2013·Haematologica·Robin FoàGianluca Gaidano
Jan 1, 2010·Mediterranean Journal of Hematology and Infectious Diseases·Maria L Delioukina, Stephen J Forman
Jan 1, 2010·Mediterranean Journal of Hematology and Infectious Diseases·Luca LaurentiSimona Sica
Dec 4, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Fabienne McClanahan, Peter Dreger
Dec 3, 2014·Hematology/oncology Clinics of North America·Fabienne McClanahan, John Gribben
Oct 14, 2014·Leukemia & Lymphoma·Racquel D Innis-SheltonShin Mineishi
Feb 3, 2015·Leukemia & Lymphoma·Constantine S Tam, Stephan Stilgenbauer
May 21, 2009·Expert Opinion on Investigational Drugs·Hui K GanJennifer J Knox
Apr 9, 2013·Hematology/oncology Clinics of North America·Andrea Schnaiter, Stephan Stilgenbauer
Mar 26, 2011·Blood Reviews·Thorsten ZenzStephan Stilgenbauer
Dec 15, 2010·Critical Reviews in Oncology/hematology·I García-EscobarH Cortés-Funes
Jul 14, 2010·Best Practice & Research. Clinical Haematology·Thorsten ZenzStephan Stilgenbauer
Aug 1, 2009·Blood Reviews·Julio DelgadoJorge Sierra
Aug 18, 2009·Leukemia Research·Tadeusz Robak
Apr 10, 2009·Hematological Oncology·Constantine S Tam, Issa Khouri
Sep 3, 2013·British Journal of Haematology·Kirsty Cuthill, Stephen Devereux
Jan 10, 2012·British Journal of Haematology·Julio DelgadoUNKNOWN Grupo Español de Citogenetica Hematologica
Oct 13, 2012·British Journal of Haematology·David OscierUNKNOWN British Committee for Standards in Haematology
Nov 28, 2013·Pediatric Blood & Cancer·Marlise LuskinAlison Loren
Feb 17, 2015·Future Oncology·Philip A ThompsonMichael J Keating

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