Allogeneic hematopoietic stem cell transplantation in Tunisia

Bone Marrow Transplantation
T Ben OthmanA Ben Abdeladhim

Abstract

In 1998, the Tunisian team of the 'Centre National de Greffe de Moelle Osseuse' initiated allogeneic hematopoietic SCT (AHSCT) in Tunisia. As of June 2007, information was collected about 299 patients with a first AHSCT and 12 additional retransplants. The median age was 19 years (range 2-49 years). The main indications were aplastic anemia (n=106, 36%), leukemia and nonmalignant disorders (n=153, 51%), Fanconi anemia (n=26, 9%) and other nonmalignant disorders (n=14, 4%). Preparative regimens depended on indication. All donors were HLA geno-identical. The stem cell sources were BM (87%) and PBSCs (13%). At the time of analysis, 200 patients (67%) were alive after a median follow-up of 42 months (range 3-112 months). The overall TRM rate was 17%. Outcome depended on indication. According to our results, allogeneic HSCT is potentially curative for hematological diseases, but it is a toxic approach for malignant disorders.

References

Jan 11, 2007·Bone Marrow Transplantation·A GratwohlUNKNOWN European Group for Blood and Marrow Transplantation EBMT

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Citations

Jan 30, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mahmoud AljurfHassan El Solh
Aug 15, 2009·Current Opinion in Hematology·Alois Gratwohl, Helen Baldomero

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