Allogeneic hematopoietic stem cell transplantation in myelofibrosis: the 20-year experience of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)

Haematologica
Francesca PatriarcaGITMO

Abstract

Allogeneic stem cell transplantation is a potentially curative treatment for myelofibrosis, although its use is limited by a high rate of transplant-related mortality. In this study, we evaluated the outcome of patients with myelofibrosis who underwent allogeneic stem cell transplantation, and the impact of prognostic factors. One hundred patients were transplanted in 26 Italian centers between 1986 and 2006. We analyzed the influence of the patients' characteristics and the clinical features of their disease before stem cell transplantation and of transplant procedures on transplant-related mortality, overall survival, and relapse-free survival by means of univariate and multivariate analyses. The median age of the patients at the time of stem cell transplantation was 49 years (range, 21-68) and 90% of them had an intermediate or high Dupriez score. Forty-eight percent received a myeloablative conditioning regimen and 78% received stem cells from matched sibling donors. The cumulative incidence of engraftment at day 90 after transplant was 87% (95% CI, 0.87-0.97). The cumulative 1-year and 3-year incidences of transplant-related mortality were 35% and 43%, respectively. The estimated 3-year overall and relapse-free survival ra...Continue Reading

Citations

Apr 29, 2010·Current Hematologic Malignancy Reports·Haefaa Alchalby, Nicolaus Kröger
Feb 24, 2010·International Journal of Hematology·Alessandro Rambaldi
Jul 26, 2012·Blood Cancer Journal·K Ballen
Feb 16, 2010·Bone Marrow Transplantation·W A StewartUNKNOWN British Society for Blood and Marrow Transplantation
Jan 5, 2011·Blood·Ayalew Tefferi
Jan 1, 2014·Current Opinion in Hematology·Daria Babushok, Elizabeth Hexner
Sep 6, 2014·Best Practice & Research. Clinical Haematology·Mohamed Shanavas, Vikas Gupta
Dec 3, 2014·Hematology/oncology Clinics of North America·Rachel B Salit, H Joachim Deeg
Jul 17, 2012·Leukemia & Lymphoma·Ruben A Mesa
Dec 7, 2010·Expert Opinion on Investigational Drugs·Eugenio LuciaFortunato Morabito
Apr 23, 2015·European Journal of Haematology·Miroslaw MarkiewiczSlawomira Kyrcz-Krzemien
Nov 29, 2012·Expert Opinion on Emerging Drugs·Ehab Atallah, Srdan Verstovsek
Oct 13, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stefania BreganteAndrea Bacigalupo
Sep 16, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·H Joachim DeegEffie W Petersdorf
Aug 20, 2015·Current Hematologic Malignancy Reports·Nicolaus Kröger
Jun 21, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marie RobinUNKNOWN Eurocord and Chronic Malignancies Working Party-European Group for Blood and Marrow Transplantation (CMWP-EBMT)
Apr 3, 2012·British Journal of Haematology·Donal P McLornanClaire N Harrison
Jun 2, 2012·British Journal of Haematology·John T ReillyUNKNOWN Writing group: British Committee for Standards in Haematology
Mar 13, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marie RobinNicolaus Kröger
Apr 1, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Vikas GuptaH Joachim Deeg
Aug 25, 2015·Clinical Lymphoma, Myeloma & Leukemia·Riad El Fakih, Uday Popat
Oct 29, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Vikas GuptaWael Saber
Sep 30, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David S SnyderStephen J Forman
May 31, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ian Nivison-SmithJeff Szer
Nov 3, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Karen K BallenMukta Arora
Feb 2, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Denise M OlianskyTheresa Hahn
Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tiziano BarbuiUNKNOWN European LeukemiaNet
Jul 14, 2016·Journal of Oncology Practice·Nosha FarhadfarAyalew Tefferi

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